EMBL Grenoble, France, is a laboratory of about 70 people, located in very close proximity to two unique European facilities for research in structural biology: the nuclear reactor of the Institut Laue Langevin (ILL), which provides high flux neutron beams, and the European Synchrotron Radiation Facility (ESRF), which produces amongst the world's most intense X-ray beams.
Research at EMBL Grenoble
EMBL Grenoble has three principle activities:
- Collaboration with the ESRF and ILL to develop methods and instrumentation for structure determination by X-ray and neutron crystallography.
- Structure, assembly and host-cell interactions of viruses, and proteins involved in membrane fusion.
- Development of instruments and technologies dedicated to automated expression and crystallisation of proteins.
Within this unique environment, EMBL Grenoble has a very active in-house research unit in structural biology making use of a wide range of techniques ranging from biochemistry to computing
Close collaboration with the ILL and the ESRF in building and operating beamlines for macromolecular crystallography, in developing the associated instrumentation and techniques, and in providing biochemical laboratory facilities and expertise to help external visitors making measurements.
The close collaboration with the ESRF is organised via the EMBL-ESRF Partnership for Structural Biology (PSB), which provides an open forum for discussing scientific and technical problems associated with running synchrotron beamlines for protein crystallography.
The Unit of Host Cell Interactions (UVHCI) is a partnership between EMBL Grenoble, University Joseph Fourier (UJF) in Grenoble and the Centre National de la Recherche Scientifique (CNRS). Its objective is to foster internationally competitive research in structural and molecular biology.
EMBL Grenoble provides a number of research services to in-house and external users. The access to the four beamlines operated on the Grenoble science campus is organised in collaboration with the ESRF. Facilities in High-Throughput Crystallisation and High-Throughput Expression as well as a Deuteration Isotope Labelling Facility provide internal and external scientists with the opportunity to evaluate their samples, using state-of-the-art technologies and equipment.