Staff at EMBL

Biography

PhD 1976, Imperial College, London, UK. Postdoctoral work at EMBL Grenoble, France.
Staff scientist at EMBL Grenoble 1980-1989.
Group Leader and Head of Outstation since 1989.
Joint appointment with the Gene Expression Unit.

Publications

Crystal structures of the human and fungal cytosolic Leucyl-tRNA synthetase editing domains: A structural basis for the rational design of antifungal benzoxaboroles. Seiradake, E., Mao, W., Hernandez, V., Baker, S.J., Plattner, J.J., Alley, M.R. & Cusack, S. J Mol Biol. 2009 Jul 10;390(2):196-207. Epub 2009 May 6. PubMed

Structure and functional relevance of the Slit2 homodimerization domain. Seiradake, E., von Philipsborn, A.C., Henry, M., Fritz, M., Lortat-Jacob, H., Jamin, M., Hemrika, W., Bastmeyer, M., Cusack, S. & McCarthy, A.A. EMBO Rep. 2009 Jul;10(7):736-41. Epub 2009 Jun 5. PubMed

Design, synthesis, and evaluation of N-acyl modified sialic acids as inhibitors of adenoviruses causing epidemic keratoconjunctivitis. Johansson, S., Nilsson, E., Qian, W., Guilligay, D., Crepin, T., Cusack, S., Arnberg, N. & Elofsson, M. J Med Chem. 2009 Jun 25;52(12):3666-78. PubMed

Structure of SRP14 from the Schizosaccharomyces pombe signal recognition particle. Brooks, M.A., Ravelli, R.B., McCarthy, A.A., Strub, K. & Cusack, S. Acta Crystallogr D Biol Crystallogr. 2009 May;65(Pt 5):421-33. Epub 2009Apr 18. PubMed

[New strategy for targeting influenza virus replication] Dias, A., Bouvier, D., Cusack, S., Ruigrok, R.W. & Crepin, T. Med Sci (Paris). 2009 Apr;25(4):352-4. PubMed

The cell adhesion molecule "CAR" and sialic acid on human erythrocytes influence adenovirus in vivo biodistribution. Seiradake, E., Henaff, D., Wodrich, H., Billet, O., Perreau, M., Hippert, C., Mennechet, F., Schoehn, G., Lortat-Jacob, H., Dreja, H., Ibanes, S., Kalatzis, V., Wang, J.P., Finberg, R.W., Cusack, S. & Kremer, E.J. PLoS Pathog. 2009 Jan;5(1):e1000277. Epub 2009 Jan 2. PubMed

Diverse role of three tyrosines in binding of the RNA 5' cap to the human nuclear cap binding complex. Worch, R., Jankowska-Anyszka, M., Niedzwiecka, A., Stepinski, J., Mazza, C., Darzynkiewicz, E., Cusack, S. & Stolarski, R. J Mol Biol. 2008 Nov 8. PubMed

Structure of the C-terminal head domain of the fowl adenovirus type 1 short fibre. El Bakkouri, M., Seiradake, E., Cusack, S., Ruigrok, R.W. & Schoehn, G. Virology. 2008 Aug 15;378(1):169-76. Epub 2008 Jun 17. PubMed

Host determinant residue lysine 627 lies on the surface of a discrete, folded domain of influenza virus polymerase PB2 subunit. Tarendeau, F., Crepin, T., Guilligay, D., Ruigrok, R.W., Cusack, S. & Hart, D.J. PLoS Pathog. 2008 Aug 29;4(8):e1000136. PubMed

The structural basis for cap binding by influenza virus polymerase subunit PB2. Guilligay, D., Tarendeau, F., Resa-Infante, P., Coloma, R., Crepin, T., Sehr, P., Lewis, J.D., Ruigrok, R.W., Ortin, J., Hart, D.J. & Cusack, S. Nat Struct Mol Biol. 2008 May;15(5):500-6. Epub 2008 May 4. PubMed

[Trap the product to specifically inhibit the enzyme.] Crepin, T. & Cusack, S. Med Sci (Paris). 2007 Dec;23(12):1087-1089. PubMed

Structural insights into the mechanism and evolution of the vaccinia virus mRNA cap N7 methyl-transferase. De la Pena, M., Kyrieleis, O.J. & Cusack, S. EMBO J. 2007 Nov 28;26(23):4913-25. Epub 2007 Nov 8. PubMed

Structural insights into the Slit-Robo complex. Morlot, C., Thielens, N.M., Ravelli, R.B., Hemrika, W., Romijn, R.A., Gros, P., Cusack, S. & McCarthy, A.A. Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):14923-8. Epub 2007 Sep 11. PubMed

Production of Slit2 LRR domains in mammalian cells for structural studies and the structure of human Slit2 domain 3. Morlot, C., Hemrika, W., Romijn, R.A., Gros, P., Cusack, S. & McCarthy, A.A. Acta Crystallogr D Biol Crystallogr. 2007 Sep;63(Pt 9):961-8. Epub 2007Aug 17. PubMed

Cloning, expression, crystallization and preliminary X-ray analysis of the first two Ig domains from human roundabout 1 (Robo1). Morlot, C., Hemrika, W., Romijn, R.A., Gros, P., Cusack, S. & McCarthy, A.A. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Aug 1;63(Pt8):689-91. Epub 2007 Jul 21. PubMed

An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site. Rock, F.L., Mao, W., Yaremchuk, A., Tukalo, M., Crepin, T., Zhou, H., Zhang, Y.K., Hernandez, V., Akama, T., Baker, S.J., Plattner, J.J., Shapiro, L., Martinis, S.A., Benkovic, S.J., Cusack, S. & Alley, M.R. Science. 2007 Jun 22;316(5832):1759-61. PubMed

Three-dimensional model for the isolated recombinant influenza virus polymerase heterotrimer. Torreira, E., Schoehn, G., Fernandez, Y., Jorba, N., Ruigrok, R.W., Cusack, S., Ortin, J. & Llorca, O. Nucleic Acids Res. 2007 May 21;. PubMed

Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit. Tarendeau, F., Boudet, J., Guilligay, D., Mas, P.J., Bougault, C.M., Boulo, S., Baudin, F., Ruigrok, R.W., Daigle, N., Ellenberg, J., Cusack, S., Simorre, J.P. & Hart, D.J. Nat Struct Mol Biol. 2007 Mar;14(3):229-33. Epub 2007 Feb 25. PubMed

A methodology and an instrument for the temperature-controlled optimization of crystal growth. Budayova-Spano, M., Dauvergne, F., Audiffren, M., Bactivelane, T. & Cusack, S. Acta Crystallogr D Biol Crystallogr. 2007 Mar;63(Pt 3):339-47. Epub 2007Feb 21. PubMed

Solution structure of NOD1 CARD and mutational analysis of its interaction with the CARD of downstream kinase RICK. Manon, F., Favier, A., Nunez, G., Simorre, J.P. & Cusack, S. J Mol Biol. 2007 Jan 5;365(1):160-74. Epub 2006 Sep 29. PubMed

Structure of Dimeric SecA, the Escherichia coli Preprotein Translocase Motor. Papanikolau, Y., Papadovasilaki, M., Ravelli, R.B., McCarthy, A.A., Cusack, S., Economou, A. & Petratos, K. J Mol Biol. 2006 Dec 23;. PubMed

Structural genomics of the Epstein-Barr virus. Tarbouriech, N., Buisson, M., Geoui, T., Daenke, S., Cusack, S. & Burmeister, W.P. Acta Crystallogr D Biol Crystallogr. 2006 Oct;62(Pt 10):1276-85. Epub 2006Sep 19. PubMed

Structures of two bacterial prolyl-tRNA synthetases with and without a cis-editing domain. Crepin, T., Yaremchuk, A., Tukalo, M. & Cusack, S. Structure. 2006 Oct;14(10):1511-25. PubMed

Automation of sample mounting for macromolecular crystallography. Cipriani, F., Felisaz, F., Launer, L., Aksoy, J.S., Caserotto, H., Cusack, S., Dallery, M., di-Chiaro, F., Guijarro, M., Huet, J., Larsen, S., Lentini, M., McCarthy, J., McSweeney, S., Ravelli, R., Renier, M., Taffut, C., Thompson, A., Leonard, G.A. & Walsh, M.A. Acta Crystallogr D Biol Crystallogr. 2006 Oct;62(Pt 10):1251-9. Epub 2006Sep 19. PubMed

First steps towards effective methods in exploiting high-throughput technologies for the determination of human protein structures of high biomedical value. Banci, L., Bertini, I., Cusack, S., de Jong, R.N., Heinemann, U., Jones, E.Y., Kozielski, F., Maskos, K., Messerschmidt, A., Owens, R., Perrakis, A., Poterszman, A., Schneider, G., Siebold, C., Silman, I., Sixma, T., Stewart-Jones, G., Sussman, J.L., Thierry, J.C. & Moras, D. Acta Crystallogr D Biol Crystallogr. 2006 Oct;62(Pt 10):1208-17. Epub 2006Sep 19. PubMed

Structural and biochemical characterization of a human adenovirus 2/12 penton base chimera. Zubieta, C., Blanchoin, L. & Cusack, S. FEBS J. 2006 Sep;273(18):4336-45. PubMed

Structural and mutational analysis of human Ad37 and canine adenovirus 2 fibre heads in complex with the D1 domain of CAR. Seiradake, E., Lortat-Jacob, H., Billet, O., Kremer, E.J. & Cusack, S. J Biol Chem. 2006 Aug 21;. PubMed

Discovering new classes of Brugia malayi Asparaginyl-tRNA synthetase inhibitors and relating specificity to conformational change. Sukuru, S.C., Crepin, T., Milev, Y., Marsh, L.C., Hill, J.B., Anderson, R.J., Morris, J.C., Rohatgi, A., O'mahony, G., Grotli, M., Danel, F., Page, M.G., Hartlein, M., Cusack, S., Kron, M.A. & Kuhn, L.A. J Comput Aided Mol Des. 2006 Mar;20(3):159-78. Epub 2006 Apr 28. PubMed

Inhibition of mRNA Deadenylation by the Nuclear Cap Binding Complex (CBC). Balatsos, N.A., Nilsson, P., Mazza, C., Cusack, S. & Virtanen, A. J Biol Chem. 2006 Feb 17;281(7):4517-22. Epub 2005 Nov 28. PubMed

Contributions of conformational flexibility to Brugia malayi asparaginyl-tRNA synthetase specificity for inhibitors identified by structure-based screening Sukuru, SCK; Crepin, T; Morris, JC; Grotli, M; Danel, F; Page, MGP; Haertlein, M; Cusack, S; Kron, MA; Kuhn, LA. Abstracts of papers of the American Chemical Society 231 March 2006 (231)

Crystal structure of enteric adenovirus serotype 41 short fiber head. Seiradake, E. & Cusack, S. J Virol 2005 Nov;79(22):14088-94. PubMed

The crystal structure of leucyl-tRNA synthetase complexed with tRNA(Leu) in the post-transfer-editing conformation. Tukalo, M., Yaremchuk, A., Fukunaga, R., Yokoyama, S. & Cusack, S. Nat Struct Mol Biol 2005 Oct;12(10):923-930. Epub 2005 Sep 11. PubMed

Specificity of recognition of mRNA 5' cap by human nuclear cap-binding complex. Worch, R., Niedzwiecka, A., Stepinski, J., Mazza, C., Jankowska-Anyszka, M., Darzynkiewicz, E., Cusack, S. & Stolarski, R. RNA 2005 Sep;11(9):1355-63. Epub 2005 Jul 25. PubMed

The Monomeric dUTPase from Epstein-Barr Virus Mimics Trimeric dUTPases. Tarbouriech, N., Buisson, M., Seigneurin, J.M., Cusack, S. & Burmeister, W.P. Structure (Camb) 2005 Sep;13(9):1299-310. PubMed

X-ray crystallographic and NMR studies of the third KH domain of hnRNP K in complex with single-stranded nucleic acids. Backe, P.H., Messias, A.C., Ravelli, R.B.G., Sattler, M. & Cusack, S. Structure (Camb) 2005 Jul;13(7):1055-67. PubMed

Significance of the first transcribed nucleoside of capped RNA for ligand-induced folding of the cap-binding complex. Worch, R., Niedzwiecka, A., Stepinski, J., Jankowska-Anyszka, M., Mazza, C., Darzynkiewicz, E., Cusack, S. & Stolarski, R. Journal of Physics-condensed Matter 2005 May;17(18):1495-1502.

A quasi-atomic model of human adenovirus type 5 capsid. Fabry, C.M., Rosa-Calatrava, M., Conway, J.F., Zubieta, C., Cusack, S., Ruigrok, R.W. & Schoehn, G. EMBO J 2005 May 4;24(9):1645-54. Epub 2005 Apr 21. PubMed

Adenovirus complex structures. Cusack, S. Curr Opin Struct Biol 2005 Apr;15(2):237-43. PubMed

The structure of the human adenovirus 2 penton. Zubieta, C., Schoehn, G., Chroboczek, J. & Cusack, S. Mol Cell 2005 Jan 7;17(1):121-35. PubMed

Novel way of capping mRNA trimer and studies of its interaction with human nuclear cap-binding complex. Worch, R., Stepinski, J., Niedzwiecka, A., Jankowska-Anyszka, M., Mazza, C., Cusack, S., Stolarski, R. & Darzynkiewicz, E. Nucleosides Nucleotides Nucleic Acids 2005;24(5-7):1131-4. PubMed

Crystal structure of species D adenovirus fiber knobs and their sialic acid binding sites. Burmeister, W.P., Guilligay, D., Cusack, S., Wadell, G. & Arnberg, N. J Virol 2004 Jul;78(14):7727-36. PubMed

The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3. Kadlec, J., Izaurralde, E. & Cusack, S. Nat Struct Mol Biol 2004 Apr;11(4):330-7. Epub 2004 Mar 7. PubMed

Crystallization, microPIXE and preliminary crystallographic analysis of the complex between the third KH domain of hnRNP K and single-stranded DNA. Backe, P.H., Ravelli, R.B.G., Garman, E. & Cusack, S. Acta Crystallogr D Biol Crystallogr 2004 Apr;60(Pt 4):784-7. Epub 2004 Mar23. PubMed

Seryl-tRNA synthetase. Weygand Durasevic, I. & Cusack, S. In: "Aminoacyl-tRNA Synthetasees", Ibba, M., Francklyn, C., & Cusack, S. (Eds.), Landes Biosciences, 2004

Prolyl-tRNA synthetase. Musier-Forsyth, K., Burke, B. & Cusack, S. In: "Aminoacyl-tRNA Synthetasees", Ibba, M., Francklyn, C., & Cusack, S. (Eds.), Landes Biosciences, 2004

Conserved tertiary base pairing ensures proper RNA folding and efficient assembly of the signal recognition particle Alu domain. Huck, L., Scherrer, A., Terzi, L., Johnson, A.E., Bernstein, H.D., Cusack, S., Weichenrieder, O. & Strub, K. Nucleic Acids Res 2004 Sep 21;32(16):4915-24. Print 2004. PubMed

Structural basis for orthogonal tRNA specificities of tyrosyl-tRNA synthetases for genetic code expansion. Kobayashi, T., Nureki, O., Ishitani, R., Yaremchuk, A., Tukalo, M., Cusack, S., Sakamoto, K. & Yokoyama, S. Nat Struct Biol 2003 Jun;10(6):425-32. PubMed

Structural and mechanistic basis of pre- and posttransfer editing by leucyl-tRNA synthetase. Lincecum, T.L., Tukalo, M., Yaremchuk, A., Mursinna, R.S., Williams, A.M., Sproat, B.S., Van Den Eynde, W., Link, A., Van Calenbergh, S., Grotli, M., Martinis, S.A. & Cusack, S. Mol Cell 2003 Apr;11(4):951-63. PubMed

Structural analysis of the adaptor protein ClpS in complex with the N-terminal domain of ClpA. Zeth, K., Ravelli, R.B., Paal, K., Cusack, S., Bukau, B. & Dougan, D.A. Nat Struct Biol 2002 Dec;9(12):906-11. PubMed

Co-crystallization of the human nuclear cap-binding complex with a m7GpppG cap analogue using protein engineering. Mazza, C., Segref, A., Mattaj, I.W. & Cusack, S. Acta Crystallogr D Biol Crystallogr 2002 Dec;58(Pt 12):2194-7. PubMed

Large-scale induced fit recognition of an m(7)GpppG cap analogue by the human nuclear cap-binding complex. Mazza, C., Segref, A., Mattaj, I.W. & Cusack, S. EMBO J 2002 Oct 15;21(20):5548-57. PubMed

Class I tyrosyl-tRNA synthetase has a class II mode of cognate tRNA recognition. Yaremchuk, A., Kriklivyi, I., Tukalo, M. & Cusack, S. EMBO J 2002 Jul 15;21(14):3829-40. PubMed

Crystallization and preliminary X-ray analysis of the Escherichia coli adaptor protein ClpS, free and in complex with the N-terminal domain of ClpA. Zeth, K., Dougan, D.A., Cusack, S., Bukau, B. & Ravelli, R.B. Acta Crystallogr D Biol Crystallogr 2002 Jul;58(Pt 7):1207-10. PubMed

tRNA-like recognition of group I introns by a tyrosyl-tRNA synthetase. Myers, C.A., Kuhla, B., Cusack, S. & Lambowitz, A.M. Proc Natl Acad Sci U S A 2002 Mar 5;99(5):2630-5. PubMed

Towards the structure of the mammalian signal recognition particle. Wild, K., Weichenrieder, O., Strub, K., Sinning, I. & Cusack, S. Curr Opin Struct Biol 2002 Feb;12(1):72-81. PubMed

Crystal structure of an early protein-RNA assembly complex of the signal recognition particle. Wild, K., Sinning, I. & Cusack, S. Science 2001 Oct 19;294(5542):598-601. PubMed

Crystal structure of the human nuclear cap binding complex. Mazza, C., Ohno, M., Segref, A., Mattaj, I.W. & Cusack, S. Mol Cell 2001 Aug;8(2):383-96. PubMed

Structure of the fiber head of Ad3, a non-CAR-binding serotype of adenovirus. Durmort, C., Stehlin, C., Schoehn, G., Mitraki, A., Drouet, E., Cusack, S. & Burmeister, W.P. Virology 2001 Jul 5;285(2):302-12. PubMed

A succession of substrate induced conformational changes ensures the amino acid specificity of Thermus thermophilus prolyl-tRNA synthetase: comparison with histidyl-tRNA synthetase. Yaremchuk, A., Tukalo, M., Grotli, M. & Cusack, S. J Mol Biol 2001 Jun 15;309(4):989-1002. PubMed

Hierarchical assembly of the Alu domain of the mammalian signal recognition particle. Weichenrieder, O., Stehlin, C., Kapp, U., Birse, D.E., Timmins, P.A., Strub, K. & Cusack, S. RNA 2001 May;7(5):731-40. PubMed

Kinetic analysis of adenovirus fiber binding to its receptor reveals an avidity mechanism for trimeric receptor-ligand interactions. Lortat-Jacob, H., Chouin, E., Cusack, S. & van Raaij, M.J. J Biol Chem 2001 Mar 23;276(12):9009-15. PubMed

Influence of adenoviral fiber mutations on viral encapsidation, infectivity and in vivo tropism. Leissner, P., Legrand, V., Schlesinger, Y., Hadji, D.A., van Raaij, M., Cusack, S., Pavirani, A. & Mehtali, M. Gene Ther 2001 Jan;8(1):49-57. PubMed

Structure, folding and assembly of adenovirus fibers. Mitraki, A., van Raaij, M., Ruigrok, R., Cusack, S., Hernandez, J.-F. & Luckey, M. In "Self-assembling Peptide Systems in Biology, Medicine and Engineering," Kluwer Academic Publishers, Dordrecht, The Netherlands

Structure and assembly of the Alu domain of the mammalian signal recognition particle. Weichenrieder, O., Wild, K., Strub, K. & Cusack, S. Nature 2000 Nov 9;408(6809):167-73. PubMed

Dimeric structure of the coxsackievirus and adenovirus receptor D1 domain at 1.7 A resolution. van Raaij, M.J., Chouin, E., van der Zandt, H., Bergelson, J.M. & Cusack, S. Structure Fold Des 2000 Nov 15;8(11):1147-55. PubMed

Mutual conformational adaptations in antigen and antibody upon complex formation between an Fab and HIV-1 capsid protein p24. Monaco-Malbet, S., Berthet-Colominas, C., Novelli, A., Battai, N., Piga, N., Cheynet, V., Mallet, F. & Cusack, S. Structure Fold Des 2000 Oct 15;8(10):1069-77. PubMed

Crystal structure of a eukaryote/archaeon-like protyl-tRNA synthetase and its complex with tRNAPro(CGG) Yaremchuk, A., Cusack, S. & Tukalo, M. EMBO J 2000 Sep 1;19(17):4745-58. PubMed

The 2 A crystal structure of leucyl-tRNA synthetase and its complex with a leucyl-adenylate analogue. Cusack, S., Yaremchuk, A. & Tukalo, M. EMBO J 2000 May 15;19(10):2351-61 PubMed

Crystallization and preliminary crystallographic analysis of Thermus thermophilus prolyl-tRNA synthetase Yaremchuk, A., Cusack, S., Gudzera, O., Grotli, M. & Tukalo, M. Acta Crystallogr D Biol Crystallogr 2000 May;56 ( Pt 5):667-9 PubMed

Improved crystals of Thermus thermophilus prolyl-tRNA synthetase complexed with cognate tRNA obtained by crystallization from precipitate. Yaremchuk, A., Kriklivyi, I., Cusack, S. & Tukalo, M. Acta Crystallogr D Biol Crystallogr 2000 Feb;56 ( Pt 2):197-9 PubMed

Crystallization and preliminary X-ray diffraction analysis of Thermus thermophilus prolyl-tRNA synthetase. Yaremchuk, A., Cusack, S. & Tukalo, M. Acta Crystallogr D Biol Crystallogr 2000 Feb;56 ( Pt 2):195-6 PubMed

The 2 A structure of helix 6 of the human signal recognition particle Wild, K., Weichenrieder, O., Leonard, G.A. & Cusack, S. Structure Fold Des 1999 Nov 15;7(11):1345-52 PubMed

A triple beta-spiral in the adenovirus fibre shaft reveals a new structural motif for a fibrous protein. van Raaij, M.J., Mitraki, A., Lavigne, G. & Cusack, S. Nature 1999 Oct 28;401(6756):935-8 PubMed

Protein microcrystals and the design of a microdiffractometer: current experience and plans at EMBL and ESRF/ID13. Perrakis, A., Cipriani, F., Castagna, J.C., Claustre, L., Burghammer, M., Riekel, C. & Cusack, S. Acta Crystallogr D Biol Crystallogr 1999 Oct;55 ( Pt 10):1765-70 PubMed

Structure of the human adenovirus serotype 2 fiber head domain at 1.5 A resolution. van Raaij, M.J., Louis, N., Chroboczek, J. & Cusack, S. Virology 1999 Sep 30;262(2):333-43 PubMed

Head-to-tail dimers and interdomain flexibility revealed by the crystal structure of HIV-1 capsid protein (p24) complexed with a monoclonal antibody Fab. Berthet-Colominas, C., Monaco, S., Novelli, A., Sibai, G., Mallet, F. & Cusack, S. EMBO J 1999 Mar 1;18(5):1124-36 PubMed

RNA-protein complexes. Cusack, S. Curr Opin Struct Biol 1999 Feb;9(1):66-73 PubMed

Escherichia coli SecA shape and dimensions. Shilton, B., Svergun, D.I., Volkov, V.V., Koch, M.H., Cusack, S. & Economou, A. FEBS Lett 1998 Oct 2 436(2) 277-282 PubMed

Small is beautiful: protein micro-crystallography. Cusack, S., Belrhali, H., Bram, A., Burghammer, M., Perrakis, A. & Riekel, C. Nat Struct Biol 1998 Aug 5 Suppl 634-637 PubMed

The crystal structure of asparaginyl-tRNA synthetase from Thermus thermophilus and its complexes with ATP and asparaginyl-adenylate: the mechanism of discrimination between asparagine and aspartic acid. Berthet-Colominas, C., Seignovert, L., Hartlein, M., Grotli, M., Cusack, S. & Leberman, R. EMBO J 1998 May 15 17(10) 2947-2960 PubMed

tRNA(Pro) anticodon recognition by Thermus thermophilus prolyl-tRNA synthetase. Cusack, S., Yaremchuk, A., Krikliviy, I. & Tukalo, M. Structure 1998 Jan 15 6(1) 101-108 PubMed

tRNA recognition by aminoacyl-tRNA synthetases. Cusack, S., Yaremchuk, A. & Tukalo, M. IN: The many faces of tRNA. Eggleston, D.S., Prescott, C.D. & Pearson, N.D., eds. Academic Press, London, pp 55-65

Identification of a minimal Alu RNA folding domain that specifically binds SRP9/14. Weichenrieder, O., Kapp, U., Cusack, S. & Strub, K. RNA 1997 Nov;3(11):1262-74 PubMed

The crystal structure of the signal recognition particle Alu RNA binding heterodimer, SRP9/14. Birse, D.E., Kapp, U., Strub, K., Cusack, S. & Aberg, A. EMBO J 1997 Jul 1 16(13) 3757-3766 PubMed

Crystal structure analysis of the activation of histidine by Thermus thermophilus histidyl-tRNA synthetase. Aberg, A., Yaremchuk, A., Tukalo, M., Rasmussen, B. & Cusack, S. Biochemistry 1997 Mar 18;36(11):3084-94 PubMed

The crystal structures of T. thermophilus lysyl-tRNA synthetase complexed with E. coli tRNA(Lys) and a T. thermophilus tRNA(Lys) transcript: anticodon recognition and conformational changes upon binding of a lysyl-adenylate analogue. Cusack, S., Yaremchuk, A. & Tukalo, M. EMBO J 1996 Nov 15;15(22):6321-34 PubMed

The crystal structure of the ternary complex of T.thermophilus seryl- tRNA synthetase with tRNA(Ser) and a seryl-adenylate analogue reveals a conformational switch in the active site. Cusack, S., Yaremchuk, A. & Tukalo, M. EMBO J 1996 Jun 3;15(11):2834-42 PubMed

Crystallization of Thermus thermophilus histidyl-tRNA synthetase and its complex with tRNAHis. Yaremchuk, A.D., Cusack, S., Aberg, A., Gudzera, O., Kryklivyi, I. & Tukalo, M. Proteins 1995 Aug;22(4):426-8 PubMed

The structural basis for seryl-adenylate and Ap4A synthesis by seryl- tRNA synthetase. Belrhali, H., Yaremchuk, A., Tukalo, M., Berthet-Colominas, C., Rasmussen, B., Bosecke, P., Diat, O. & Cusack, S. Structure 1995 Apr 15;3(4):341-52 PubMed

Cocrystallization of lysyl-tRNA synthetase from Thermus thermophilus with its cognate tRNAlys and with Escherichia coli tRNAlys. Yaremchuk, A.D., Krikliviy, I.A., Cusack, S. & Tukalo, M.A. Proteins 1995 Mar;21(3):261-4 PubMed

Structure of influenza virus RNP. I. Influenza virus nucleoprotein melts secondary structure in panhandle RNA and exposes the bases to the solvent. Baudin, F., Bach, C., Cusack, S. & Ruigrok, R.W. EMBO J 1994 Jul 1;13(13):3158-65 PubMed

The 2.9 A crystal structure of T. thermophilus seryl-tRNA synthetase complexed with tRNA(Ser). Biou, V., Yaremchuk, A., Tukalo, M. & Cusack, S. Science 1994 Mar 11 263(5152) 1404-1410 PubMed

A small percentage of influenza virus M1 protein contains zinc but zinc does not influence in vitro M1-RNA interaction. Elster, C., Fourest, E., Baudin, F., Larsen, K., Cusack, S. & Ruigrok, R.W. J Gen Virol 1994 Jan;75 ( Pt 1):37-42 PubMed

Comparison of structure and sequence of influenza B/Yamagata and B/Beijing neuraminidases shows a conserved "head" but much greater variability in the "stalk" and NB protein. Burmeister, W.P., Baudin, F., Cusack, S. & Ruigrok, R.W. Virology 1993 Feb;192(2):683-6 PubMed

The 2.2 A resolution crystal structure of influenza B neuraminidase and its complex with sialic acid. Burmeister, W.P., Ruigrok, R.W. & Cusack, S. EMBO J 1992 Jan;11(1):49-56 PubMed

A second class of synthetase structure revealed by X-ray analysis of Escherichia coli seryl-tRNA synthetase at 2.5 A Cusack, S., Berthet-Colominas, C., Hartlein, M., Nassar, N. & Leberman, R. Nature 1990 Sep 20 347(6290) 249-255 PubMed