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Staff at EMBL


Dr. Stephen Cusack

Head of Outstation and Senior Scientist
Cusack Group

EMBL Grenoble, 71 avenue des Martyrs, CS 90181, 38042 Grenoble Cedex 9, France

E-mail: send a mail


PhD 1976, Imperial College, London, UK.
Postdoctoral work at EMBL Grenoble.
Staff scientist at EMBL Grenoble 1980-1989.
Group Leader, Senior Scientist and Head of Outstation since 1989.
Director of EMBL-Grenoble University-CNRS Unit for Virus Host Cell Interactions (UVHCI) since 2007.
ERC Advanced Investigator.


Total: 166 publication(s)


Reich S, Guilligay D, Pflug A, Malet H, Berger I, Crépin T, Hart D, Lunardi T, Nanao M, Ruigrok RW, Cusack S. (2014)
Structural insight into cap-snatching and RNA synthesis by influenza polymerase.
Nature doi:10.1038/nature14009
Europe PMC | doi

Pflug A, Guilligay D, Reich S, Cusack S. (2014)
Structure of influenza A polymerase bound to the viral RNA promoter.
Nature doi:10.1038/nature14008
Europe PMC | doi

Bousset L, Mary C, Brooks MA, Scherrer A, Strub K, Cusack S. (2014)
Crystal structure of a signal recognition particle Alu domain in the elongation arrest conformation.
RNA 20(12):1955-1962. doi:10.1261/rna.047209.114
Europe PMC | doi

Louber J, Kowalinski E, Bloyet LM, Brunel J, Cusack S, Gerlier D. (2014)
RIG-I Self-Oligomerization Is Either Dispensable or Very Transient for Signal Transduction
PLoS ONE 9(9):e108770. doi:10.1371/journal.pone.0108770
Europe PMC | doi

Xiol J, Spinelli P, Laussmann MA, Homolka D, Yang Z, Cora E, Couté Y, Conn S, Kadlec J, Sachidanandam R, Kaksonen M, Cusack S, Ephrussi A, Pillai RS. (2014)
RNA Clamping by Vasa Assembles a piRNA Amplifier Complex on Transposon Transcripts
Cell 157(7):1698-1711. doi:10.1016/j.cell.2014.05.018
Europe PMC | doi

Cvetesic N, Palencia A, Halasz I, Cusack S, Gruic-Sovulj I. (2014)
The physiological target for LeuRS translational quality control is norvaline
EMBO J. 33(15):1639-1653. doi:10.15252/embj.201488199
Europe PMC | doi

Dias J, Van Nguyen N, Georgiev P, Gaub A, Brettschneider J, Cusack S, Kadlec J, Akhtar A. (2014)
Structural analysis of the KANSL1/WDR5/KANSL2 complex reveals that WDR5 is required for efficient assembly and chromatin targeting of the NSL complex
Genes Dev. 28(9):929-942. doi:10.1101/gad.240200.114
Europe PMC | doi

Kyrieleis OJ, Chang J, de la Peña M, Shuman S, Cusack S. (2014)
Crystal structure of vaccinia virus mRNA capping enzyme provides insights into the mechanism and evolution of the capping apparatus
Structure 22(3):452-465. doi:10.1016/j.str.2013.12.014
Europe PMC | doi

Clerici M, Deniaud A, Boehm V, Gehring NH, Schaffitzel C, Cusack S. (2014)
Structural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2
Nucleic Acids Res. 42(4):2673-2686. doi:10.1093/nar/gkt1197
Europe PMC | doi

Guilligay D, Kadlec J, Crépin T, Lunardi T, Bouvier D, Kochs G, Ruigrok RW, Cusack S. (2014)
Comparative structural and functional analysis of orthomyxovirus polymerase cap-snatching domains
PLoS ONE 9(1):e84973. doi:10.1371/journal.pone.0084973
Europe PMC | doi

Reguera J, Cusack S, Kolakofsky D. (2014)
Segmented negative strand RNA virus nucleoprotein structure
Curr Opin Virol 5C:7-15. doi:10.1016/j.coviro.2014.01.003
Europe PMC | doi


Hallais M, Pontvianne F, Andersen PR, Clerici M, Lener D, Benbahouche Nel H, Gostan T, Vandermoere F, Robert MC, Cusack S, Verheggen C, Jensen TH, Bertrand E. (2013)
CBC-ARS2 stimulates 3'-end maturation of multiple RNA families and favors cap-proximal processing
Nat. Struct. Mol. Biol. 20(12):1358-1366. doi:10.1038/nsmb.2720
Europe PMC | doi

Pautus S, Sehr P, Lewis J, Fortuné A, Wolkerstorfer A, Szolar O, Guilligay D, Lunardi T, Décout JL, Cusack S. (2013)
New 7-methylguanine derivatives targeting the influenza polymerase PB2 cap-binding domain
J. Med. Chem. 56(21):8915-8930. doi:10.1021/jm401369y
Europe PMC | doi

Wu H, Mathioudakis N, Diagouraga B, Dong A, Dombrovski L, Baudat F, Cusack S, de Massy B, Kadlec J. (2013)
Molecular basis for the regulation of the H3K4 methyltransferase activity of PRDM9
Cell Rep 5(1):13-20. doi:10.1016/j.celrep.2013.08.035
Europe PMC | doi

Datta K, Wolkerstorfer A, Szolar OH, Cusack S, Klumpp K. (2013)
Characterization of PA-N terminal domain of Influenza A polymerase reveals sequence specific RNA cleavage
Nucleic Acids Res. 41(17):8289-8299. doi:10.1093/nar/gkt603
Europe PMC | doi

Klemm C, Reguera J, Cusack S, Zielecki F, Kochs G, Weber F. (2013)
Systems to establish bunyavirus genome replication in the absence of transcription
J. Virol. 87(14):8205-8212. doi:10.1128/jvi.00371-13
Europe PMC | doi

Reguera J, Malet H, Weber F, Cusack S. (2013)
Structural basis for encapsidation of genomic RNA by La Crosse Orthobunyavirus nucleoprotein
Proc. Natl. Acad. Sci. U.S.A. 110(18):7246-7251. doi:10.1073/pnas.1302298110
Europe PMC | doi

Hernandez V, Crépin T, Palencia A, Cusack S, Akama T, Baker SJ, Bu W, Feng L, Freund YR, Liu L, Meewan M, Mohan M, Mao W, Rock FL, Sexton H, Sheoran A, Zhang Y, Zhang YK, Zhou Y, Nieman JA, Anugula MR, Keramane el M, Savariraj K, Reddy DS, Sharma R, Subedi R, Singh R, O'Leary A, Simon NL, De Marsh PL, Mushtaq S, Warner M, Livermore DM, Alley MR, Plattner JJ. (2013)
Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria
Antimicrob. Agents Chemother. 57(3):1394-1403. doi:10.1128/aac.02058-12
Europe PMC | doi

Li L, Palencia A, Lukk T, Li Z, Luthey-Schulten ZA, Cusack S, Martinis SA, Boniecki MT. (2013)
Leucyl-tRNA synthetase editing domain functions as a molecular rheostat to control codon ambiguity in Mycoplasma pathogens
Proc. Natl. Acad. Sci. U.S.A. 110(10):3817-3822. doi:10.1073/pnas.1218374110
Europe PMC | doi

Chopra S, Palencia A, Virus C, Tripathy A, Temple BR, Velazquez-Campoy A, Cusack S, Reader JS. (2013)
Plant tumour biocontrol agent employs a tRNA-dependent mechanism to inhibit leucyl-tRNA synthetase
Nat Commun 4:1417. doi:10.1038/ncomms2421
Europe PMC | doi


Kolakofsky D, Kowalinski E, Cusack S. (2012)
A structure-based model of RIG-I activation
RNA 18(12):2118-2127. doi:10.1261/rna.035949.112
Europe PMC | doi

Avilov SV, Moisy D, Naffakh N, Cusack S. (2012)
Influenza A virus progeny vRNP trafficking in live infected cells studied with the virus-encoded fluorescently tagged PB2 protein
Vaccine 30(51):7411-7417. doi:10.1016/j.vaccine.2012.09.077
Europe PMC | doi

Hallacli E, Lipp M, Georgiev P, Spielman C, Cusack S, Akhtar A, Kadlec J. (2012)
Msl1-mediated dimerization of the dosage compensation complex is essential for male X-chromosome regulation in Drosophila
Mol. Cell 48(4):587-600. doi:10.1016/j.molcel.2012.09.014
Europe PMC | doi

Mathioudakis N, Palencia A, Kadlec J, Round A, Tripsianes K, Sattler M, Pillai RS, Cusack S. (2012)
The multiple Tudor domain-containing protein TDRD1 is a molecular scaffold for mouse Piwi proteins and piRNA biogenesis factors
RNA 18(11):2056-2072. doi:10.1261/rna.034181.112
Europe PMC | doi

Palencia A, Crépin T, Vu MT, Lincecum TL Jr, Martinis SA, Cusack S. (2012)
Structural dynamics of the aminoacylation and proofreading functional cycle of bacterial leucyl-tRNA synthetase
Nat. Struct. Mol. Biol. 19(7):677-684. doi:10.1038/nsmb.2317
Europe PMC | doi

Avilov SV, Moisy D, Munier S, Schraidt O, Naffakh N, Cusack S. (2012)
Replication-competent influenza A virus that encodes a split-green fluorescent protein-tagged PB2 polymerase subunit allows live-cell imaging of the virus life cycle
J. Virol. 86(3):1433-1448. doi:10.1128/jvi.05820-11
Europe PMC | doi

Kowalinski E, Louber J, Gerlier D, Cusack S. (2012)
[RIG-I: a viral RNA detector molecular switch]
Med Sci (Paris) 28(2):136-138. doi:10.1051/medsci/2012282006
Europe PMC | doi

Kowalinski E, Zubieta C, Wolkerstorfer A, Szolar OH, Ruigrok RW, Cusack S. (2012)
Structural analysis of specific metal chelating inhibitor binding to the endonuclease domain of influenza pH1N1 (2009) polymerase
PLoS Pathog. 8(8):e1002831. doi:10.1371/journal.ppat.1002831
Europe PMC | doi

Szolajska E, Burmeister WP, Zochowska M, Nerlo B, Andreev I, Schoehn G, Andrieu JP, Fender P, Naskalska A, Zubieta C, Cusack S, Chroboczek J. (2012)
The structural basis for the integrity of adenovirus Ad3 dodecahedron
PLoS ONE 7(9):e46075. doi:10.1371/journal.pone.0046075
Europe PMC | doi


Kowalinski E, Lunardi T, McCarthy AA, Louber J, Brunel J, Grigorov B, Gerlier D, Cusack S. (2011)
Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA
Cell 147(2):423-435. doi:10.1016/j.cell.2011.09.039
Europe PMC | doi

Russi S, Juers DH, Sanchez-Weatherby J, Pellegrini E, Mossou E, Forsyth VT, Huet J, Gobbo A, Felisaz F, Moya R, McSweeney SM, Cusack S, Cipriani F, Bowler MW. (2011)
Inducing phase changes in crystals of macromolecules: status and perspectives for controlled crystal dehydration
J. Struct. Biol. 175(2):236-243. doi:10.1016/j.jsb.2011.03.002
Europe PMC | doi

Perrakis A, Musacchio A, Cusack S, Petosa C. (2011)
Investigating a macromolecular complex: the toolkit of methods
J. Struct. Biol. 175(2):106-112. doi:10.1016/j.jsb.2011.05.014
Europe PMC | doi

Kadlec J, Hallacli E, Lipp M, Holz H, Sanchez-Weatherby J, Cusack S, Akhtar A. (2011)
Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1
Nat. Struct. Mol. Biol. 18(2):142-149. doi:10.1038/nsmb.1960
Europe PMC | doi

Crepin T, Peterson F, Haertlein M, Jensen D, Wang C, Cusack S, Kron M. (2011)
A hybrid structural model of the complete Brugia malayi cytoplasmic asparaginyl-tRNA synthetase
J. Mol. Biol. 405(4):1056-1069. doi:10.1016/j.jmb.2010.11.049
Europe PMC | doi


Boivin S, Cusack S, Ruigrok RW, Hart DJ. (2010)
Influenza A virus polymerase: structural insights into replication and host adaptation mechanisms
J. Biol. Chem. 285(37):28411-28417. doi:10.1074/jbc.r110.117531
Europe PMC | doi

Crépin T, Dias A, Palencia A, Swale C, Cusack S, Ruigrok RW. (2010)
Mutational and metal binding analysis of the endonuclease domain of the influenza virus polymerase PA subunit
J. Virol. 84(18):9096-9104. doi:10.1128/jvi.00995-10
Europe PMC | doi

Mourão A, Varrot A, Mackereth CD, Cusack S, Sattler M. (2010)
Structure and RNA recognition by the snRNA and snoRNA transport factor PHAX
RNA 16(6):1205-1216. doi:10.1261/rna.2009910
Europe PMC | doi

Huet S, Avilov SV, Ferbitz L, Daigle N, Cusack S, Ellenberg J. (2010)
Nuclear import and assembly of influenza A virus RNA polymerase studied in live cells by fluorescence cross-correlation spectroscopy
J. Virol. 84(3):1254-1264. doi:10.1128/jvi.01533-09
Europe PMC | doi

Ruigrok RW, Crépin T, Hart DJ, Cusack S. (2010)
Towards an atomic resolution understanding of the influenza virus replication machinery
Curr. Opin. Struct. Biol. 20(1):104-113. doi:10.1016/
Europe PMC | doi

Chenavas S, Guilligay D, Cusack S, Hart DJ, Ruigrok RWH, Crépin T. (2010)
Avancées dans l'étude structurale et la compréhension moléculaire du mécanisme de transcription du virus de la grippe [Advances in the structural study and molecular comprehension of the transcription mechanism of influenza virus]
Virologie 14(6):435-445. doi:10.1684/vir.2010.0328
Europe PMC | doi

Reguera J, Weber F, Cusack S. (2010)
Bunyaviridae RNA polymerases (L-protein) have an N-terminal, influenza-like endonuclease domain, essential for viral cap-dependent transcription
PLoS Pathog. 6(9):e1001101. doi:10.1371/journal.ppat.1001101
Europe PMC | doi


Clerici M, Mourão A, Gutsche I, Gehring NH, Hentze MW, Kulozik A, Kadlec J, Sattler M, Cusack S. (2009)
Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2
EMBO J. 28(15):2293-2306. doi:10.1038/emboj.2009.175
Europe PMC | doi

Seiradake E, Mao W, Hernandez V, Baker SJ, Plattner JJ, Alley MR, Cusack S. (2009)
Crystal structures of the human and fungal cytosolic Leucyl-tRNA synthetase editing domains: A structural basis for the rational design of antifungal benzoxaboroles
J. Mol. Biol. 390(2):196-207. doi:10.1016/j.jmb.2009.04.073
Europe PMC | doi

Seiradake E, von Philipsborn AC, Henry M, Fritz M, Lortat-Jacob H, Jamin M, Hemrika W, Bastmeyer M, Cusack S, McCarthy AA. (2009)
Structure and functional relevance of the Slit2 homodimerization domain
EMBO Rep. 10(7):736-741. doi:10.1038/embor.2009.95
Europe PMC | doi

Johansson S, Nilsson E, Qian W, Guilligay D, Crepin T, Cusack S, Arnberg N, Elofsson M. (2009)
Design, synthesis, and evaluation of N-acyl modified sialic acids as inhibitors of adenoviruses causing epidemic keratoconjunctivitis
J. Med. Chem. 52(12):3666-3678. doi:10.1021/jm801609s
Europe PMC | doi

Brooks MA, Ravelli RB, McCarthy AA, Strub K, Cusack S. (2009)
Structure of SRP14 from the Schizosaccharomyces pombe signal recognition particle
Acta Crystallogr. D Biol. Crystallogr. 65(Pt 5):421-433. doi:10.1107/s0907444909005484
Europe PMC | doi

Dias A, Bouvier D, Cusack S, Ruigrok RW, Crépin T. (2009)
[New strategy for targeting influenza virus replication]
Med Sci (Paris) 25(4):352-354. doi:10.1051/medsci/2009254352
Europe PMC | doi

Dias A, Bouvier D, Crépin T, McCarthy AA, Hart DJ, Baudin F, Cusack S, Ruigrok RW. (2009)
The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit
Nature 458(7240):914-918. doi:10.1038/nature07745
Europe PMC | doi

Worch R, Jankowska-Anyszka M, Niedzwiecka A, Stepinski J, Mazza C, Darzynkiewicz E, Cusack S, Stolarski R. (2009)
Diverse role of three tyrosines in binding of the RNA 5' cap to the human nuclear cap binding complex
J. Mol. Biol. 385(2):618-627. doi:10.1016/j.jmb.2008.10.092
Europe PMC | doi

Seiradake E, Henaff D, Wodrich H, Billet O, Perreau M, Hippert C, Mennechet F, Schoehn G, Lortat-Jacob H, Dreja H, Ibanes S, Kalatzis V, Wang JP, Finberg RW, Cusack S, Kremer EJ. (2009)
The cell adhesion molecule "CAR" and sialic acid on human erythrocytes influence adenovirus in vivo biodistribution
PLoS Pathog. 5(1):e1000277. doi:10.1371/journal.ppat.1000277
Europe PMC | doi


El Bakkouri M, Seiradake E, Cusack S, Ruigrok RW, Schoehn G. (2008)
Structure of the C-terminal head domain of the fowl adenovirus type 1 short fibre
Virology 378(1):169-176. doi:10.1016/j.virol.2008.05.011
Europe PMC | doi

Guilligay D, Tarendeau F, Resa-Infante P, Coloma R, Crepin T, Sehr P, Lewis J, Ruigrok RW, Ortin J, Hart DJ, Cusack S. (2008)
The structural basis for cap binding by influenza virus polymerase subunit PB2
Nat. Struct. Mol. Biol. 15(5):500-506. doi:10.1038/nsmb.1421
Europe PMC | doi

Tarendeau F, Crepin T, Guilligay D, Ruigrok RW, Cusack S, Hart DJ. (2008)
Host determinant residue lysine 627 lies on the surface of a discrete, folded domain of influenza virus polymerase PB2 subunit
PLoS Pathog. 4(8):e1000136. doi:10.1371/journal.ppat.1000136
Europe PMC | doi


Crépin T, Cusack S. (2007)
[Trap the product to specifically inhibit the enzyme]
Med Sci (Paris) 23(12):1087-1089. doi:10.1051/medsci/200723121087
Europe PMC | doi

De la Peña M, Kyrieleis OJ, Cusack S. (2007)
Structural insights into the mechanism and evolution of the vaccinia virus mRNA cap N7 methyl-transferase
EMBO J. 26(23):4913-4925. doi:10.1038/sj.emboj.7601912
Europe PMC | doi

Morlot C, Hemrika W, Romijn RA, Gros P, Cusack S, McCarthy AA. (2007)
Production of Slit2 LRR domains in mammalian cells for structural studies and the structure of human Slit2 domain 3
Acta Crystallogr. D Biol. Crystallogr. 63(Pt 9):961-968. doi:10.1107/s0907444907035470
Europe PMC | doi

Morlot C, Thielens NM, Ravelli RB, Hemrika W, Romijn RA, Gros P, Cusack S, McCarthy AA. (2007)
Structural insights into the Slit-Robo complex
Proc. Natl. Acad. Sci. U.S.A. 104(38):14923-14928. doi:10.1073/pnas.0705310104
Europe PMC | doi

Morlot C, Hemrika W, Romijn RA, Gros P, Cusack S, McCarthy AA. (2007)
Cloning, expression, crystallization and preliminary X-ray analysis of the first two Ig domains from human roundabout 1 (Robo1)
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 63(Pt 8):689-691. doi:10.1107/S1744309107033027
Europe PMC | doi

Rock FL, Mao W, Yaremchuk A, Tukalo M, Crépin T, Zhou H, Zhang YK, Hernandez V, Akama T, Baker SJ, Plattner JJ, Shapiro L, Martinis SA, Benkovic SJ, Cusack S, Alley MR. (2007)
An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site
Science 316(5832):1759-1761. doi:10.1126/science.1142189
Europe PMC | doi

Budayova-Spano M, Dauvergne F, Audiffren M, Bactivelane T, Cusack S. (2007)
A methodology and an instrument for the temperature-controlled optimization of crystal growth
Acta Crystallogr. D Biol. Crystallogr. 63(Pt 3):339-347. doi:10.1107/s0907444906054230
Europe PMC | doi

Tarendeau F, Boudet J, Guilligay D, Mas PJ, Bougault CM, Boulo S, Baudin F, Ruigrok RW, Daigle N, Ellenberg J, Cusack S, Simorre JP, Hart DJ. (2007)
Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit
Nat. Struct. Mol. Biol. 14(3):229-233. doi:10.1038/nsmb1212
Europe PMC | doi

Papanikolau Y, Papadovasilaki M, Ravelli RB, McCarthy AA, Cusack S, Economou A, Petratos K. (2007)
Structure of dimeric SecA, the Escherichia coli preprotein translocase motor
J. Mol. Biol. 366(5):1545-1557. doi:10.1016/j.jmb.2006.12.049
Europe PMC | doi

Manon F, Favier A, Núñez G, Simorre JP, Cusack S. (2007)
Solution structure of NOD1 CARD and mutational analysis of its interaction with the CARD of downstream kinase RICK
J. Mol. Biol. 365(1):160-174. doi:10.1016/j.jmb.2006.09.067
Europe PMC | doi

Torreira E, Schoehn G, Fernández Y, Jorba N, Ruigrok RW, Cusack S, Ortín J, Llorca O. (2007)
Three-dimensional model for the isolated recombinant influenza virus polymerase heterotrimer
Nucleic Acids Res. 35(11):3774-3783. doi:10.1093/nar/gkm336
Europe PMC | doi


Seiradake E, Lortat-Jacob H, Billet O, Kremer EJ, Cusack S. (2006)
Structural and mutational analysis of human Ad37 and canine adenovirus 2 fiber heads in complex with the D1 domain of coxsackie and adenovirus receptor
J. Biol. Chem. 281(44):33704-33716. doi:10.1074/jbc.m605316200
Europe PMC | doi

Cipriani F, Felisaz F, Launer L, Aksoy JS, Caserotto H, Cusack S, Dallery M, di-Chiaro F, Guijarro M, Huet J, Larsen S, Lentini M, McCarthy J, McSweeney S, Ravelli R, Renier M, Taffut C, Thompson A, Leonard GA, Walsh MA. (2006)
Automation of sample mounting for macromolecular crystallography
Acta Crystallogr. D Biol. Crystallogr. 62(Pt 10):1251-1259. doi:10.1107/s0907444906030587
Europe PMC | doi

Kadlec J, Guilligay D, Ravelli RB, Cusack S. (2006)
Crystal structure of the UPF2-interacting domain of nonsense-mediated mRNA decay factor UPF1
RNA 12(10):1817-1824. doi:10.1261/rna.177606
Europe PMC | doi

Banci L, Bertini I, Cusack S, de Jong RN, Heinemann U, Jones EY, Kozielski F, Maskos K, Messerschmidt A, Owens R, Perrakis A, Poterszman A, Schneider G, Siebold C, Silman I, Sixma T, Stewart-Jones G, Sussman JL, Thierry JC, Moras D. (2006)
First steps towards effective methods in exploiting high-throughput technologies for the determination of human protein structures of high biomedical value
Acta Crystallogr. D Biol. Crystallogr. 62(Pt 10):1208-1217. doi:10.1107/s0907444906029350
Europe PMC | doi

Beteva A, Cipriani F, Cusack S, Delageniere S, Gabadinho J, Gordon EJ, Guijarro M, Hall DR, Larsen S, Launer L, Lavault CB, Leonard GA, Mairs T, McCarthy A, McCarthy J, Meyer J, Mitchell E, Monaco S, Nurizzo D, Pernot P, Pieritz R, Ravelli RG, Rey V, Shepard W, Spruce D, Stuart DI, Svensson O, Theveneau P, Thibault X, Turkenburg J, Walsh M, McSweeney SM. (2006)
High-throughput sample handling and data collection at synchrotrons: embedding the ESRF into the high-throughput gene-to-structure pipeline
Acta Crystallogr. D Biol. Crystallogr. 62(Pt 10):1162-1169. doi:10.1107/s0907444906032859
Europe PMC | doi

Tarbouriech N, Buisson M, Géoui T, Daenke S, Cusack S, Burmeister WP. (2006)
Structural genomics of the Epstein-Barr virus
Acta Crystallogr. D Biol. Crystallogr. 62(Pt 10):1276-1285. doi:10.1107/s0907444906030034
Europe PMC | doi

Crepin T, Yaremchuk A, Tukalo M, Cusack S. (2006)
Structures of two bacterial prolyl-tRNA synthetases with and without a cis-editing domain
Structure 14(10):1511-1525. doi:10.1016/j.str.2006.08.007
Europe PMC | doi

Zubieta C, Blanchoin L, Cusack S. (2006)
Structural and biochemical characterization of a human adenovirus 2/12 penton base chimera
FEBS J. 273(18):4336-4345. doi:10.1111/j.1742-4658.2006.05430.x
Europe PMC | doi

Sukuru SC, Crepin T, Milev Y, Marsh LC, Hill JB, Anderson RJ, Morris JC, Rohatgi A, O'Mahony G, Grøtli M, Danel F, Page MG, Härtlein M, Cusack S, Kron MA, Kuhn LA. (2006)
Discovering new classes of Brugia malayi asparaginyl-tRNA synthetase inhibitors and relating specificity to conformational change
J. Comput. Aided Mol. Des. 20(3):159-178. doi:10.1007/s10822-006-9043-5
Europe PMC | doi

Balatsos NA, Nilsson P, Mazza C, Cusack S, Virtanen A. (2006)
Inhibition of mRNA deadenylation by the nuclear cap binding complex (CBC)
J. Biol. Chem. 281(7):4517-4522. doi:10.1074/jbc.m508590200
Europe PMC | doi

Sukuru SCK, Crepin T, Morris JC, Grotli M, Danel F, Page MGP, Haertlein M, Cusack S, Kron MA, Kuhn LA. (2006)
Contributions of conformational flexibility to Brugia malayi asparaginyl-tRNA synthetase specificity for inhibitors identified by structure-based screening
Abstracts of papers of the American Chemical Society 231:N/A.
Europe PMC


Seiradake E, Cusack S. (2005)
Crystal structure of enteric adenovirus serotype 41 short fiber head
J. Virol. 79(22):14088-14094. doi:10.1128/jvi.79.22.14088-14094.2005
Europe PMC | doi

Tukalo M, Yaremchuk A, Fukunaga R, Yokoyama S, Cusack S. (2005)
The crystal structure of leucyl-tRNA synthetase complexed with tRNALeu in the post-transfer-editing conformation
Nat. Struct. Mol. Biol. 12(10):923-930. doi:10.1038/nsmb986
Europe PMC | doi

Worch R, Niedzwiecka A, Stepinski J, Mazza C, Jankowska-Anyszka M, Darzynkiewicz E, Cusack S, Stolarski R. (2005)
Specificity of recognition of mRNA 5' cap by human nuclear cap-binding complex
RNA 11(9):1355-1363. doi:10.1261/rna.2850705
Europe PMC | doi

Tarbouriech N, Buisson M, Seigneurin JM, Cusack S, Burmeister WP. (2005)
The monomeric dUTPase from Epstein-Barr virus mimics trimeric dUTPases
Structure 13(9):1299-1310. doi:10.1016/j.str.2005.06.009
Europe PMC | doi

Backe PH, Messias AC, Ravelli RB, Sattler M, Cusack S. (2005)
X-ray crystallographic and NMR studies of the third KH domain of hnRNP K in complex with single-stranded nucleic acids
Structure 13(7):1055-1067. doi:10.1016/j.str.2005.04.008
Europe PMC | doi

Fabry CM, Rosa-Calatrava M, Conway JF, Zubieta C, Cusack S, Ruigrok RW, Schoehn G. (2005)
A quasi-atomic model of human adenovirus type 5 capsid
EMBO J. 24(9):1645-1654. doi:10.1038/sj.emboj.7600653
Europe PMC | doi

Cusack S. (2005)
Adenovirus complex structures
Curr. Opin. Struct. Biol. 15(2):237-243. doi:10.1016/
Europe PMC | doi

Musier-Forsyth K, Burke B, Cusack, S. (2005)
Prolyl-tRNA synthetase
In: Ibba M, Francklyn C, Cusack S (eds.), Aminoacyl-tRNA Synthetases. Intelligence Unit. Landes Bioscience. pp 149-161.

Weygand-Durasevic I, Cusack S. (2005)
Seryl-tRNA Synthetases
In: Ibba M, Francklyn C, Cusack S (eds.), Aminoacyl-tRNA Synthetases. Intelligence Unit. Landes Bioscience. pp 177-192.
Europe PMC

Worch R, Stepinski J, Niedzwiecka A, Jankowska-Anyszka M, Mazza C, Cusack S, Stolarski R, Darzynkiewicz E. (2005)
Novel way of capping mRNA trimer and studies of its interaction with human nuclear cap-binding complex
Paper presented at the 16th International Roundtable of the International-Society-for-Nucleosides-Nucleotides-and-Nucleic-Acids (IS3NA), Minneapolis, MN, SEP 12-16, 2004.Nucleosides Nucleotides Nucleic Acids 24(5-7):1131-1134. doi:10.1081/ncn-200061898
Europe PMC | doi

Worch R, Niedzwiecka A, Stepinski J, Jankowska-Anyszka M, Mazza C, Darzynkiewicz E, Cusack S, Stolarski R. (2005)
Significance of the first transcribed nucleoside of capped RNA for ligand-induced folding of the cap-binding complex
J Phys Condens Matter 17(18):S1495-S1502.
Europe PMC

Zubieta C, Schoehn G, Chroboczek J, Cusack S. (2005)
The structure of the human adenovirus 2 penton
Mol. Cell 17(1):121-135. doi:10.1016/j.molcel.2004.11.041
Europe PMC | doi


Burmeister WP, Guilligay D, Cusack S, Wadell G, Arnberg N. (2004)
Crystal structure of species D adenovirus fiber knobs and their sialic acid binding sites
J. Virol. 78(14):7727-7736. doi:10.1128/jvi.78.14.7727-7736.2004
Europe PMC | doi

Backe PH, Ravelli RB, Garman E, Cusack S. (2004)
Crystallization, microPIXE and preliminary crystallographic analysis of the complex between the third KH domain of hnRNP K and single-stranded DNA
Acta Crystallogr. D Biol. Crystallogr. 60(Pt 4):784-787. doi:10.1107/s0907444904002628
Europe PMC | doi

Kadlec J, Izaurralde E, Cusack S. (2004)
The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3
Nat. Struct. Mol. Biol. 11(4):330-337. doi:10.1038/nsmb741
Europe PMC | doi

Huck L, Scherrer A, Terzi L, Johnson AE, Bernstein HD, Cusack S, Weichenrieder O, Strub K. (2004)
Conserved tertiary base pairing ensures proper RNA folding and efficient assembly of the signal recognition particle Alu domain
Nucleic Acids Res. 32(16):4915-4924. doi:10.1093/nar/gkh837
Europe PMC | doi


Kobayashi T, Nureki O, Ishitani R, Yaremchuk A, Tukalo M, Cusack S, Sakamoto K, Yokoyama S. (2003)
Structural basis for orthogonal tRNA specificities of tyrosyl-tRNA synthetases for genetic code expansion
Nat. Struct. Biol. 10(6):425-432. doi:10.1038/nsb934
Europe PMC | doi

Lincecum TL Jr, Tukalo M, Yaremchuk A, Mursinna RS, Williams AM, Sproat BS, Van Den Eynde W, Link A, Van Calenbergh S, Grøtli M, Martinis SA, Cusack S. (2003)
Structural and mechanistic basis of pre- and posttransfer editing by leucyl-tRNA synthetase
Mol. Cell 11(4):951-963. doi:10.1016/s1097-2765(03)00098-4
Europe PMC | doi


Mazza C, Segref A, Mattaj IW, Cusack S. (2002)
Co-crystallization of the human nuclear cap-binding complex with a m7GpppG cap analogue using protein engineering
Acta Crystallogr. D Biol. Crystallogr. 58(Pt 12):2194-2197. doi:10.1107/s0907444902015445
Europe PMC | doi

Zeth K, Ravelli RB, Paal K, Cusack S, Bukau B, Dougan DA. (2002)
Structural analysis of the adaptor protein ClpS in complex with the N-terminal domain of ClpA
Nat. Struct. Biol. 9(12):906-911. doi:10.1038/nsb869
Europe PMC | doi

Mazza C, Segref A, Mattaj IW, Cusack S. (2002)
Large-scale induced fit recognition of an m(7)GpppG cap analogue by the human nuclear cap-binding complex
EMBO J. 21(20):5548-5557. doi:10.1093/emboj/cdf538
Europe PMC | doi

Yaremchuk A, Kriklivyi I, Tukalo M, Cusack S. (2002)
Class I tyrosyl-tRNA synthetase has a class II mode of cognate tRNA recognition
EMBO J. 21(14):3829-3840. doi:10.1093/emboj/cdf373
Europe PMC | doi

Zeth K, Dougan DA, Cusack S, Bukau B, Ravelli RB. (2002)
Crystallization and preliminary X-ray analysis of the Escherichia coli adaptor protein ClpS, free and in complex with the N-terminal domain of ClpA
Acta Crystallogr. D Biol. Crystallogr. 58(Pt 7):1207-1210. doi:10.1107/s0907444902006960
Europe PMC | doi

Myers CA, Kuhla B, Cusack S, Lambowitz AM. (2002)
tRNA-like recognition of group I introns by a tyrosyl-tRNA synthetase
Proc. Natl. Acad. Sci. U.S.A. 99(5):2630-2635. doi:10.1073/pnas.052596299
Europe PMC | doi

Wild K, Weichenrieder O, Strub K, Sinning I, Cusack S. (2002)
Towards the structure of the mammalian signal recognition particle
Curr. Opin. Struct. Biol. 12(1):72-81. doi:10.1016/s0959-440x(02)00292-0
Europe PMC | doi