Staff at EMBL
Dr. Babu A. Manjasetty
Staff Scientist
EMBL-ESRF India Project
EMBL Grenoble, BP 181, 6 rue Jules Horowitz, 38042 Grenoble Cedex 9, France
| E-mail: | send a mail |
|---|
Biography
PhD in Physics, 1994, University Grants Commission Doctoral Fellow, University of Mysore, India.
Lecturer, Govt. Science College, Bangalore / Visiting Researcher, IISc, Bangalore, India:1994-1998.
Alexander von Humboldt Research Fellow, Berlin, Germany: 1998-2000.
Postdoctoral work at University of California at Santa Cruz, USA; Biotechnology Research Institute, Montreal, Canada; Max Delbruck Center for Molecular Medicine, Berlin, Germany: 2000-2004.
Scientist at Brookhaven National Laboratory, New York / Case Western Reserve University, USA : 2004-2009.
Staff Scientist at EMBL Grenoble, France since 2010.
Publications
Structure-function relationships of two paralogous single-stranded DNA binding proteins from Streptomyces coelicolor: implication of SSB-B in chromosome segregation during sporulation. Paradzik, T., Ivic, N., Filic, Z., Manjasetty, B.A., Herron, P., Luic, M. & Vujaklija, D. Nucleic Acids Res. 2013. (Accepted).
Structural and functional conservation profiles of novel cathepsin L-like proteins identified in the Drosophila melanogaster genome. Kumar, S., Farmer, R., Turnbull, A.P., Tripathy, N.K. & Manjasetty, B.A. J Biomol Struct Dyn. 2012 Dec 21. PubMed
Analysis of conformational variation in macromolecular structural models. Srivastava, S.K., Gayathri, S., Manjasetty, B.A. & Gopal, B. PLoS One. 2012;7(7):e39993. doi: 10.1371/journal.pone.0039993. Epub 2012 Jul 9. PubMed
Structural basis for modification of flavonol and naphthol glucoconjugates by Nicotiana tabacum malonyltransferase (NtMaT1). Manjasetty, B.A., Yu, X.H., Panjikar, S., Taguchi, G., Chance, M.R. & Liu, C.J. Planta. 2012 Sep;236(3):781-93. doi: 10.1007/s00425-012-1660-8. Epub 2012 May 19. PubMed
Analysis of Conformational Variation in Macromolecular Structural Models. Srivastava, S.K., Gayathri S, Manjasetty, B.A., Gopal, B. PLoS One 2012, 7 (7):1-14. doi: 10.1371/journal.pone.0039993.
Current methods in structural proteomics and its applications in biological sciences. Manjasetty, B.A., Büssow, K., Panjikar, S. & Turnbull, A. 3 Biotech 2012, 2:89113. Review. doi: 10.1007/s13205-011-0037-1
Inducing phase transitions in protein crystals by controlled crystal dehydration. Russi, S., Manjasetty, B.A., McCarthy, A., Cipriani, F. & Belrhali, H. Acta Cryst. (2011). A67, C811
Preliminary crystallography confirms that the archaeal DNA-binding and tryptophan-sensing regulator TrpY is a dimer. Cafasso, J., Manjasetty, B.A., Karr, E.A., Sandman, K., Chance, M.R. & Reeve, J.N. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Nov 1;66(Pt 11):1493-5.Epub 2010 Oct 28. PubMed
The impact of structural proteomics on biotechnology. Manjasetty, B., Turnbull, A. & Panjikar, S. Biotechnol Genet Eng Rev. 2010;26:353-70. PubMed
Automated technologies and novel techniques to accelerate protein crystallography for structural genomics. Manjasetty, B.A., Turnbull, A.P., Panjikar, S., Bussow, K. & Chance, M.R. Proteomics. 2008 Feb;8(4):612-25. PubMed
A Proposed Suite of Macromolecular Crystallography Facilities for NSLS-II. Berman LE, Allaire M, Chance M, Hendrickson W, Heroux A, Manjasetty BA, Orville A, Robinson H, Saxena A, Schneider D, Shi W, Soares A, Stojanoff V, Sweet R. Acta Cryst., 2008, A64, C175.
Crystal Structure of Mn2+ bound E. coli L-arabinose Isomerase: Its implications in Protein Catalytic Mechanism and Thermo-Stability. Zhu, W., Chance, M.R., Manjasetty, B.A. J Young Investigators 2007; 17(3).
A high-throughput approach to protein structure analysis. Manjasetty, B.A., Shi, W., Zhan, C., Fiser, A., Chance, M.R. Genet. Eng. (N.Y.) 2007, 28:105128. ISBN: 978-0-387-33840-8 Book Chapter.
Crystal structure of Escherichia coli L-arabinose isomerase (ECAI), the putative target of biological tagatose production. Manjasetty, B.A. & Chance, M.R. J Mol Biol. 2006 Jul 7;360(2):297-309. Epub 2006 May 5. PubMed
Crystal structure of Homo sapiens PTD012 reveals a zinc-containing hydrolase fold. Manjasetty, B.A., Bussow, K., Fieber-Erdmann, M., Roske, Y., Gobom, J., Scheich, C., Gotz, F., Niesen, F.H. & Heinemann, U. Protein Sci. 2006 Apr;15(4):914-20. Epub 2006 Mar 7. PubMed
Recent Advances in Protein Structure Analysis. Manjasetty BA, Turnbull A, Büssow K, Chance, MR. Recent Res. Devel. Biochem., 2006, 7: 47-71. ISBN: 81-308-0076-4 Book Chapter.
The ybeY protein from Escherichia coli is a metalloprotein. Zhan, C., Fedorov, E.V., Shi, W., Ramagopal, U.A., Thirumuruhan, R., Manjasetty, B.A., Almo, S.C., Fiser, A., Chance, M.R. & Fedorov, A.A. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Nov 1;61(Pt 11):959-63.Epub 2005 Oct 20. PubMed
Metalloproteomics: high-throughput structural and functional annotation of proteins in structural genomics. Shi, W., Zhan, C., Ignatov, A., Manjasetty, B.A., Marinkovic, N., Sullivan, M., Huang, R. & Chance, M.R. Structure. 2005 Oct;13(10):1473-86. PubMed
X-ray structure of engineered human Aortic Preferentially Expressed Protein-1 (APEG-1). Manjasetty, B.A., Niesen, F.H., Scheich, C., Roske, Y., Goetz, F., Behlke, J., Sievert, V., Heinemann, U. & Bussow, K. BMC Struct Biol. 2005 Dec 14;5:21. PubMed
X-ray structure of fumarylacetoacetate hydrolase family member Homo sapiens FLJ36880. Manjasetty, B.A., Niesen, F.H., Delbruck, H., Gotz, F., Sievert, V., Bussow, K., Behlke, J. & Heinemann, U. Biol Chem. 2004 Oct;385(10):935-42. PubMed
X-ray structure of human gankyrin, the product of a gene linked to hepatocellular carcinoma. Manjasetty, B.A., Quedenau, C., Sievert, V., Bussow, K., Niesen, F., Delbruck, H. & Heinemann, U. Proteins. 2004 Apr 1;55(1):214-7. PubMed
Crystal structure of Homo sapiens protein hp14.5. Manjasetty, B.A., Delbruck, H., Pham, D.T., Mueller, U., Fieber-Erdmann, M., Scheich, C., Sievert, V., Bussow, K., Niesen, F.H., Weihofen, W., Loll, B., Saenger, W. & Heinemann, U. Proteins. 2004 Mar 1;54(4):797-800. PubMed
Structure of circularly permuted DsbA(Q100T99): preserved global fold and local structural adjustments. Manjasetty, B.A., Hennecke, J., Glockshuber, R. & Heinemann, U. Acta Crystallogr D Biol Crystallogr. 2004 Feb;60(Pt 2):304-9. Epub 2004 Jan 23. PubMed
Crystal structure of a bifunctional aldolase-dehydrogenase: sequestering a reactive and volatile intermediate. Manjasetty, B.A., Powlowski, J. & Vrielink, A. Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6992-7. Epub 2003 May 22. PubMed
Secure web book to store structural genomics research data. Manjasetty, B.A., Hoppner, K., Mueller, U. & Heinemann, U. J Struct Funct Genomics. 2003;4(2-3):121-7. PubMed
Crystallization and preliminary X-ray analysis of dmpFG-encoded 4-hydroxy-2-ketovalerate aldolase--aldehyde dehydrogenase (acylating) from Pseudomonas sp. strain CF600. Manjasetty, B.A., Croteau, N., Powlowski, J. & Vrielink, A. Acta Crystallogr D Biol Crystallogr. 2001 Apr;57(Pt 4):582-5. PubMed
Crystal structures of recombinant histones HMfA and HMfB from the hyperthermophilic archaeon Methanothermus fervidus. Decanniere, K., Babu, A.M., Sandman, K., Reeve, J.N. & Heinemann, U. J Mol Biol. 2000 Oct 13;303(1):35-47. PubMed
Crystal structure of 1,4 butane di-ammonium di(ethanedioate) monohydrate (putrescinium (2+) di (hydrogen oxalate) monohydrate 2:1 complex. Manjasetty, B.A., Weakley, T.J.R., Murthy, M.R.N. Z Kristallogr New Cryst Struct 1998; 213:321-322.
Extended conformation of putrescine occurring on a centre of symmetry in its 1:2 complex with malonic acid. Manjasetty, B.A., Weakley, T.J.R., Murthy, M.R.N. Acta Cryst 1997; C53:365-367.