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Staff at EMBL

Dr. Andrew McCarthy

Team Leader
McCarthy Team

EMBL Grenoble, 71 avenue des Martyrs, CS 90181, 38042 Grenoble Cedex 9, France

E-mail: send a mail


PhD 1997, National University of Ireland, Galway.
Research associate, Utrecht University.
Postdoctoral research at Massey University and Auckland University.
Staff scientist at EMBL Grenoble.
Team leader since 2007.


The MID-PIWI module of Piwi proteins specifies nucleotide- and strand-biases of piRNAs. Cora, E., Pandey, R.R., Xiol, J., Taylor, J., Sachidanandam, R., McCarthy, A.A. & Pillai, R.S. RNA. 2014 Jun;20(6):773-81. doi: 10.1261/rna.044701.114. Epub 2014 Apr 22. Europe PMC

The use of a mini-kappa goniometer head in macromolecular crystallography diffraction experiments. Brockhauser, S., Ravelli, R.B. & McCarthy, A.A. Acta Crystallogr D Biol Crystallogr. 2013 Jul;69(Pt 7):1241-51. doi:10.1107/S0907444913003880. Epub 2013 Jun 15. Europe PMC

Automatic processing of macromolecular crystallography X-ray diffraction data at the ESRF. Monaco, S., Gordon, E., Bowler, M.W., Delageniere, S., Guijarro, M., Spruce, D., Svensson, O., McSweeney, S.M., McCarthy, A.A., Leonard, G. & Nanao, M.H. J Appl Crystallogr. 2013 Jun 1;46(Pt 3):804-810. Epub 2013 May 15. Europe PMC

A structural basis for the biosynthesis of the major chlorogenic acids found in coffee. Lallemand, L.A., Zubieta, C., Lee, S.G., Wang, Y., Acajjaoui, S., Timmins, J., McSweeney, S., Jez, J.M., McCarthy, J.G. & McCarthy, A.A. Plant Physiol. 2012 Sep;160(1):249-60. doi: 10.1104/pp.112.202051. Epub 2012 Jul20. Europe PMC

The use of workflows in the design and implementation of complex experiments in macromolecular crystallography. Brockhauser, S., Svensson, O., Bowler, M.W., Nanao, M., Gordon, E., Leal, R.M., Popov, A., Gerring, M., McCarthy, A.A. & Gotz, A. Acta Crystallogr D Biol Crystallogr. 2012 Aug;68(Pt 8):975-84. Epub 2012 Jul 17. Europe PMC

Purification, crystallization and preliminary X-ray diffraction analysis of a hydroxycinnamoyl-CoA shikimate/quinate hydroxycinnamoyltransferase (HCT) from Coffea canephora involved in chlorogenic acid biosynthesis. Lallemand, L.A., McCarthy, J.G., McSweeney, S. & McCarthy, A.A. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jul 1;68(Pt 7):824-8. doi:10.1107/S1744309112019082. Epub 2012 Jun 28. Europe PMC

Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA. Kowalinski, E., Lunardi, T., McCarthy, A.A., Louber, J., Brunel, J., Grigorov, B., Gerlier, D. & Cusack, S. Cell. 2011 Oct 14;147(2):423-35. Europe PMC

Translation calibration of inverse-kappa goniometers in macromolecular crystallography. Brockhauser, S., White, K.I., McCarthy, A.A. & Ravelli, R.B. Acta Crystallogr A. 2011 May;67(Pt 3):219-28. Epub 2011 Mar 15. Europe PMC

Visualizing the metal-binding versatility of copper trafficking sites . Badarau, A., Firbank, S.J., McCarthy, A.A., Banfield, M.J. & Dennison, C. Biochemistry. 2010 Sep 14;49(36):7798-810. Europe PMC

MxCuBE: a synchrotron beamline control environment customized for macromolecular crystallography experiments. Gabadinho, J., Beteva, A., Guijarro, M., Rey-Bakaikoa, V., Spruce, D., Bowler, M.W., Brockhauser, S., Flot, D., Gordon, E.J., Hall, D.R., Lavault, B., McCarthy, A.A., McCarthy, J., Mitchell, E., Monaco, S., Mueller-Dieckmann, C., Nurizzo, D., Ravelli, R.B., Thibault, X., Walsh, M.A., Leonard, G.A. & McSweeney, S.M. J Synchrotron Radiat. 2010 Sep;17(5):700-7. Epub 2010 Jul 13. Europe PMC

Structural basis of HIV-1 tethering to membranes by the BST-2/tetherin ectodomain. Hinz, A., Miguet, N., Natrajan, G., Usami, Y., Yamanaka, H., Renesto, P., Hartlieb, B., McCarthy, A.A., Simorre, J.P., Gottlinger, H. & Weissenhorn, W. Cell Host Microbe. 2010 Apr 22;7(4):314-23. Europe PMC

A decade of user operation on the macromolecular crystallography MAD beamline ID14-4 at the ESRF. McCarthy, A.A., Brockhauser, S., Nurizzo, D., Theveneau, P., Mairs, T., Spruce, D., Guijarro, M., Lesourd, M., Ravelli, R.B. & McSweeney, S. J Synchrotron Radiat. 2009 Nov;16(Pt 6):803-12. Epub 2009 Oct 7. Europe PMC

The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit. Dias, A., Bouvier, D., Crepin, T., McCarthy, A.A., Hart, D.J., Baudin, F., Cusack, S. & Ruigrok, R.W. Nature. 2009 Apr 16;458(7240):914-8. Epub 2009 Feb 4. Europe PMC

Capturing the Shape of Macromolecular Crystals in 3D Leal, R.M.F. Teixeira, S.C.M. Rey, V. Forsyth, V.T. Mitchel, E.P. Brockhauser, S. Di Michiel, M. McGeehan, J.E. McCarthy, A., Ravelli, R.B.G ESRF Highlights 2008, 127-129

X-ray tomographic reconstruction of macromolecular samples. Brockhauser, S., Di Michiel, M. McGeehan, J. E., McCarthy, A. A., Ravelli, R. B. G. J. Appl. Cryst. 2008 41 1057-1066

Structural insights into the Slit-Robo complex. Morlot, C., Thielens, N.M., Ravelli, R.B., Hemrika, W., Romijn, R.A., Gros, P., Cusack, S. & McCarthy, A.A. Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):14923-8. Epub 2007 Sep 11. Europe PMC

Production of Slit2 LRR domains in mammalian cells for structural studies and the structure of human Slit2 domain 3. Morlot, C., Hemrika, W., Romijn, R.A., Gros, P., Cusack, S. & McCarthy, A.A. Acta Crystallogr D Biol Crystallogr. 2007 Sep;63(Pt 9):961-8. Epub 2007Aug 17. Europe PMC

Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase. Martinez Molina, D., Wetterholm, A., Kohl, A., McCarthy, A.A., Niegowski, D., Ohlson, E., Hammarberg, T., Eshaghi, S., Haeggstrom, J.Z. & Nordlund, P. Nature. 2007 Aug 2;448(7153):613-6. Epub 2007 Jul 15. Europe PMC

Cloning, expression, crystallization and preliminary X-ray analysis of the first two Ig domains from human roundabout 1 (Robo1). Morlot, C., Hemrika, W., Romijn, R.A., Gros, P., Cusack, S. & McCarthy, A.A. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Aug 1;63(Pt8):689-91. Epub 2007 Jul 21. Europe PMC

The structure of two N-methyltransferases from the caffeine biosynthetic pathway. McCarthy, A.A. & McCarthy, J.G. Plant Physiol. 2007 Jun;144(2):879-89. Epub 2007 Apr 13. Europe PMC

Cloning, expression, crystallization and preliminary X-ray analysis of the XMT and DXMT N-methyltransferases from Coffea canephora (robusta). McCarthy, A.A., Biget, L., Lin, C., Petiard, V., Tanksley, S.D. & McCarthy, J.G. Acta Crystallograph Sect F Struct Biol Cryst Commun. 2007 Apr 1;63(Pt4):304-7. Epub 2007 Mar 12. Europe PMC

Structure of dimeric SecA, the Escherichia coli preprotein translocase motor. Papanikolau, Y., Papadovasilaki, M., Ravelli, R.B., McCarthy, A.A., Cusack, S., Economou, A. & Petratos, K. J Mol Biol. 2007 Mar 9;366(5):1545-57. Epub 2006 Dec 23. Europe PMC

Plastic-embedded protein crystals. Ravelli, R.B., Haselmann-Weiss, U., McGeehan, J.E., McCarthy, A.A., Marquez, J.A., Antony, C., Frangakis, A.S. & Stranzl, G. J Synchrotron Radiat. 2007 Jan 1;14(Pt 1):128-32. Epub 2006 Dec 15. Europe PMC

Structure of C3b reveals conformational changes that underlie complement activity. Janssen, B.J., Christodoulidou, A., McCarthy, A., Lambris, J.D. & Gros, P. Nature. 2006 Nov 9;444(7116):213-6. Epub 2006 Oct 15. Europe PMC

Structural analysis of Bordetella pertussis BugE solute receptor in a bound conformation. Huvent, I., Belrhali, H., Antoine, R., Bompard, C., Locht, C., Jacob-Dubuisson, F. & Villeret, V. Acta Crystallogr D Biol Crystallogr. 2006 Nov;62(Pt 11):1375-81. Epub 2006Oct 18. Europe PMC

High-throughput sample handling and data collection at synchrotrons: embedding the ESRF into the high-throughput gene-to-structure pipeline. Beteva, A., Cipriani, F., Cusack, S., Delageniere, S., Gabadinho, J., Gordon, E.J., Guijarro, M., Hall, D.R., Larsen, S., Launer, L., Lavault, C.B., Leonard, G.A., Mairs, T., McCarthy, A., McCarthy, J., Meyer, J., Mitchell, E., Monaco, S., Nurizzo, D., Pernot, P., Pieritz, R., Ravelli, R.G., Rey, V., Shepard, W., Spruce, D., Stuart, D.I., Svensson, O., Theveneau, P., Thibault, X., Turkenburg, J., Walsh, M. & McSweeney, S.M. Acta Crystallogr D Biol Crystallogr. 2006 Oct;62(Pt 10):1162-9. Epub 2006 Sep 19. Europe PMC

The care and nurture of undulator data sets. Flot, D., Gordon, E.J., Hall, D.R., Leonard, G.A., McCarthy, A., McCarthy, J., McSweeney, S., Mitchell, E., Nurizzo, D., Ravelli, R.B.G. & Shepard, W. Acta Crystallogr D Biol Crystallogr. 2006 Jan;62(Pt 1):65-71. Epub 2005Dec 14. Europe PMC

Automation of macromolecular crystallography beamlines. Arzt, S., Beteva, A., Cipriani, F., Delageniere, S., Felisaz, F., Forstner, G., Gordon, E., Launer, L., Lavault, B., Leonard, G., Mairs, T., McCarthy, A., McCarthy, J., McSweeney, S., Meyer, J., Mitchell, E., Monaco, S., Nurizzo, D., Ravelli, R.B.G., Rey, V., Shepard, W., Spruce, D., Svensson, O. & Theveneau, P. Prog Biophys Mol Biol 2005 Oct;89(2):124-52. Europe PMC

Structure and function of the C-terminal domain of the polymerase cofactor of rabies virus. Mavrakis, M., McCarthy, A.A., Roche, S., Blondel, D. & Ruigrok, R.W. J Mol Biol 2004 Oct 29;343(4):819-31. Europe PMC

Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes. Harel, M., Aharoni, A., Gaidukov, L., Brumshtein, B., Khersonsky, O., Meged, R., Dvir, H., Ravelli, R.B., McCarthy, A., Toker, L., Silman, I., Sussman, J.L. & Tawfik, D.S. Nat Struct Mol Biol 2004 May;11(5):412-9. Epub 2004 Apr 18. Europe PMC

Crystal structure of MshB from Mycobacterium tuberculosis, a deacetylase involved in mycothiol biosynthesis. McCarthy, A.A., Peterson, N.A., Knijff, R. & Baker, E.N. J Mol Biol 2004 Jan 23;335(4):1131-41. Europe PMC