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Staff at EMBL

Dr. Daniel Panne

Group Leader
Panne Group Joint appointment: Genome Biology Unit

EMBL Grenoble, 71 avenue des Martyrs, CS 90181, 38042 Grenoble Cedex 9, France

E-mail: send a mail


PhD 1999, University of Basel.
Postdoctoral research at Harvard University, Boston.
Group Leader at EMBL Grenoble since 2007.


Immunology: Cytosolic DNA sensing unraveled. Panne, D. Nat Chem Biol. 2013 Sep;9(9):533-4. doi: 10.1038/nchembio.1318. Europe PMC

Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation. Delvecchio, M., Gaucher, J., Aguilar-Gurrieri, C., Ortega, E. & Panne, D. Nat Struct Mol Biol. 2013 Sep;20(9):1040-6. doi: 10.1038/nsmb.2642. Epub 2013 Aug11. Europe PMC

Crystal structure and mechanism of activation of TANK-binding kinase 1. Larabi, A., Devos, J.M., Ng, S.L., Nanao, M.H., Round, A., Maniatis, T. & Panne, D. Cell Rep. 2013 Mar 28;3(3):734-46. doi: 10.1016/j.celrep.2013.01.034. Epub 2013Feb 28. Europe PMC

Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains. Reynoird, N., Schwartz, B.E., Delvecchio, M., Sadoul, K., Meyers, D., Mukherjee, C., Caron, C., Kimura, H., Rousseaux, S., Cole, P.A., Panne, D., French, C.A. & Khochbin, S. EMBO J. 2010 Sep 1;29(17):2943-52. Epub 2010 Jul 30. Europe PMC

Recognition of AT-rich DNA binding sites by the MogR repressor. Shen, A., Higgins, D.E. & Panne, D. Structure. 2009 May 13;17(5):769-77. doi: 10.1016/j.str.2009.02.018. Europe PMC

The enhanceosome. Panne, D. Curr Opin Struct Biol. 2008 Apr;18(2):236-42. Epub 2008 Feb 21. Europe PMC

Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch. Panne, D., McWhirter, S.M., Maniatis, T. & Harrison, S.C. J Biol Chem. 2007 Aug 3;282(31):22816-22. Epub 2007 May 25. Europe PMC

An atomic model of the interferon-beta enhanceosome. Panne, D., Maniatis, T. & Harrison, S.C. Cell. 2007 Jun 15;129(6):1111-23. Europe PMC

Crystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-beta enhancer. Panne, D., Maniatis, T. & Harrison, S.C. EMBO J. 2004 Nov 10;23(22):4384-93. Epub 2004 Oct 28. Europe PMC

The McrBC restriction endonuclease assembles into a ring structure in the presence of G nucleotides. Panne, D., Muller, S.A., Wirtz, S., Engel, A. & Bickle, T.A. EMBO J. 2001 Jun 15;20(12):3210-7. Europe PMC

Methyl-specific DNA binding by McrBC, a modification-dependent restriction enzyme. Stewart, F.J., Panne, D., Bickle, T.A. & Raleigh, E.A. J Mol Biol. 2000 May 12;298(4):611-22. Europe PMC

Protein trans-splicing and cyclization by a naturally split intein from the dnaE gene of Synechocystis species PCC6803. Evans TC, J.r, Martin, D., Kolly, R., Panne, D., Sun, L., Ghosh, I., Chen, L., Benner, J., Liu, X.Q. & Xu, M.Q. J Biol Chem. 2000 Mar 31;275(13):9091-4. Europe PMC

The McrBC endonuclease translocates DNA in a reaction dependent on GTP hydrolysis. Panne, D., Raleigh, E.A. & Bickle, T.A. J Mol Biol. 1999 Jul 2;290(1):49-60. Europe PMC

McrBs, a modulator peptide for McrBC activity. Panne, D., Raleigh, E.A. & Bickle, T.A. EMBO J. 1998 Sep 15;17(18):5477-83. Europe PMC

Control of protein splicing by intein fragment reassembly. Southworth, M.W., Adam, E., Panne, D., Byer, R., Kautz, R. & Perler, F.B. EMBO J. 1998 Feb 16;17(4):918-26. Europe PMC