EMBL Grenoble, 71 avenue des Martyrs, CS 90181, 38042 Grenoble Cedex 9, France

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  • PhD 2002, University of Bern.
    Postdoctoral research at the Friedrich Miescher Institute, Basel.
    Group Leader at EMBL Grenoble since 2006.
    ERC Investigator.


Total: 37 publication(s)


Yang Z, Chen KM, Pandey RR, Homolka D, Reuter M, Janeiro BK, Sachidanandam R, Fauvarque MO, McCarthy AA, Pillai RS. (2016)

PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from Cytosolic Targets of the Mouse piRNA Pathway.

Mol. Cell 61(1):138-152. doi:10.1016/j.molcel.2015.11.009
Europe PMC | doi


Homolka D, Pandey RR, Goriaux C, Brasset E, Vaury C, Sachidanandam R, Fauvarque M-O, Pillai RS. (2015)

PIWI Slicing and RNA Elements in Precursors Instruct Directional Primary piRNA Biogenesis.

Cell Rep 12(3):1-11. doi:10.1016/j.celrep.2015.06.030
Europe PMC | doi

Chen KM, Campbell E, Pandey RR, Yang Z, McCarthy AA, Pillai RS. (2015)

Metazoan Maelstrom is an RNA-binding protein that has evolved from an ancient nuclease active in protists.

RNA doi:10.1261/rna.049437.114
Europe PMC | doi

Vourekas A, Zheng K, Fu Q, Maragkakis M, Alexiou P, Ma J, Pillai RS, Mourelatos Z, Wang PJ. (2015)

The RNA helicase MOV10L1 binds piRNA precursors to initiate piRNA processing.

Genes Dev doi:10.1101/gad.254631.114
Europe PMC | doi


Yang Z, Pillai RS. (2014)

Fly piRNA biogenesis: tap dancing with Tej.

BMC Biol. 12 doi:10.1186/s12915-014-0077-1
Europe PMC | doi

Pandey RR, Pillai RS. (2014)

Primary piRNA biogenesis: caught up in a Maelstrom

EMBO J 33(18):1979-1980. doi:10.15252/embj.201489670
Europe PMC | doi

Cora E, Pandey RR, Xiol J, Taylor J, Sachidanandam R, McCarthy AA, Pillai RS. (2014)

The MID-PIWI module of Piwi proteins specifies nucleotide- and strand-biases of piRNAs

RNA 20(6):773-781. doi:10.1261/rna.044701.114
Europe PMC | doi

Xiol J, Spinelli P, Laussmann MA, Homolka D, Yang Z, Cora E, Couté Y, Conn S, Kadlec J, Sachidanandam R, Kaksonen M, Cusack S, Ephrussi A, Pillai RS. (2014)

RNA Clamping by Vasa Assembles a piRNA Amplifier Complex on Transposon Transcripts

Cell 157(7):1698-1711. doi:10.1016/j.cell.2014.05.018
Europe PMC | doi

Klenov MS, Lavrov SA, Korbut AP, Stolyarenko AD, Yakushev EY, Reuter M, Pillai RS, Gvozdev VA. (2014)

Impact of nuclear Piwi elimination on chromatin state in Drosophila melanogaster ovaries

Nucleic Acids Res. 42(10):6208-6218. doi:10.1093/nar/gku268
Europe PMC | doi

Reuter M, Pillai RS. (2014)

Analysis of small RNA-guided endonuclease activity in endogenous Piwi protein complexes from mouse testes

Methods Mol. Biol. 1093:111-121. doi:10.1007/978-1-62703-694-8_9
Europe PMC | doi


Pandey RR, Tokuzawa Y, Yang Z, Hayashi E, Ichisaka T, Kajita S, Asano Y, Kunieda T, Sachidanandam R, Chuma S, Yamanaka S, Pillai RS. (2013)

Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice

Proc. Natl. Acad. Sci. U.S.A. 110(41):16492-16497. doi:10.1073/pnas.1316316110
Europe PMC | doi

Muller S, Raman Pandey R, Pillai RS. (2013)

[The piRNAs forge an immune system for the genome]

Med Sci (Paris) 29(5):487-494. doi:10.1051/medsci/2013295011
Europe PMC | doi


Voigt F, Reuter M, Kasaruho A, Schulz EC, Pillai RS, Barabas O. (2012)

Crystal structure of the primary piRNA biogenesis factor Zucchini reveals similarity to the bacterial PLD endonuclease Nuc

RNA 18(12):2128-2134. doi:10.1261/rna.034967.112
Europe PMC | doi

Mathioudakis N, Palencia A, Kadlec J, Round A, Tripsianes K, Sattler M, Pillai RS, Cusack S. (2012)

The multiple Tudor domain-containing protein TDRD1 is a molecular scaffold for mouse Piwi proteins and piRNA biogenesis factors

RNA 18(11):2056-2072. doi:10.1261/rna.034181.112
Europe PMC | doi

Xiol J, Cora E, Koglgruber R, Chuma S, Subramanian S, Hosokawa M, Reuter M, Yang Z, Berninger P, Palencia A, Benes V, Penninger J, Sachidanandam R, Pillai RS. (2012)

A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing

Mol. Cell 47(6):970-979. doi:10.1016/j.molcel.2012.07.019
Europe PMC | doi

Xiol J, Pillai RS. (2012)

Molecular biology. Outsourcing genome protection

Science 337(6094):529-530. doi:10.1126/science.1227095
Europe PMC | doi

Pillai RS, Chuma S. (2012)

piRNAs and their involvement in male germline development in mice

Dev. Growth Differ. 54(1):78-92. doi:10.1111/j.1440-169x.2011.01320.x
Europe PMC | doi


Reuter M, Berninger P, Chuma S, Shah H, Hosokawa M, Funaya C, Antony C, Sachidanandam R, Pillai RS. (2011)

Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing

Nature 480(7376):264-267. doi:10.1038/nature10672
Europe PMC | doi

Tanaka T, Hosokawa M, Vagin VV, Reuter M, Hayashi E, Mochizuki AL, Kitamura K, Yamanaka H, Kondoh G, Okawa K, Kuramochi-Miyagawa S, Nakano T, Sachidanandam R, Hannon GJ, Pillai RS, Nakatsuji N, Chuma S. (2011)

Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis

Proc. Natl. Acad. Sci. U.S.A. 108(26):10579-10584. doi:10.1073/pnas.1015447108
Europe PMC | doi

Simon B, Kirkpatrick JP, Eckhardt S, Reuter M, Rocha EA, Andrade-Navarro MA, Sehr P, Pillai RS, Carlomagno T. (2011)

Recognition of 2'-O-methylated 3'-end of piRNA by the PAZ domain of a Piwi protein

Structure 19(2):172-180. doi:10.1016/j.str.2010.11.015
Europe PMC | doi


Zheng K, Xiol J, Reuter M, Eckardt S, Leu NA, McLaughlin KJ, Stark A, Sachidanandam R, Pillai RS, Wang PJ. (2010)

Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway

Proc. Natl. Acad. Sci. U.S.A. 107(26):11841-11846. doi:10.1073/pnas.1003953107
Europe PMC | doi


Chuma S, Pillai RS. (2009)

Retrotransposon silencing by piRNAs: ping-pong players mark their sub-cellular boundaries

PLoS Genet. 5(12):e1000770. doi:10.1371/journal.pgen.1000770
Europe PMC | doi

Shoji M, Tanaka T, Hosokawa M, Reuter M, Stark A, Kato Y, Kondoh G, Okawa K, Chujo T, Suzuki T, Hata K, Martin SL, Noce T, Kuramochi-Miyagawa S, Nakano T, Sasaki H, Pillai RS, Nakatsuji N, Chuma S. (2009)

The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline

Dev. Cell 17(6):775-787. doi:10.1016/j.devcel.2009.10.012
Europe PMC | doi

Reuter M, Chuma S, Tanaka T, Franz T, Stark A, Pillai RS. (2009)

Loss of the Mili-interacting Tudor domain-containing protein-1 activates transposons and alters the Mili-associated small RNA profile

Nat. Struct. Mol. Biol. 16(6):639-646. doi:10.1038/nsmb.1615
Europe PMC | doi


Mathonnet G, Fabian MR, Svitkin YV, Parsyan A, Huck L, Murata T, Biffo S, Merrick WC, Darzynkiewicz E, Pillai RS, Filipowicz W, Duchaine TF, Sonenberg N. (2007)

MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F

Science 317(5845):1764-1767. doi:10.1126/science.1146067
Europe PMC | doi

Pillai RS, Bhattacharyya SN, Filipowicz W. (2007)

Repression of protein synthesis by miRNAs: how many mechanisms?

Trends Cell Biol. 17(3):118-126. doi:10.1016/j.tcb.2006.12.007
Europe PMC | doi


Schmitter D, Filkowski J, Sewer A, Pillai RS, Oakeley EJ, Zavolan M, Svoboda P, Filipowicz W. (2006)

Effects of Dicer and Argonaute down-regulation on mRNA levels in human HEK293 cells

Nucleic Acids Res. 34(17):4801-4815. doi:10.1093/nar/gkl646
Europe PMC | doi


Pillai RS. (2005)

MicroRNA function: multiple mechanisms for a tiny RNA?

RNA 11(12):1753-1761. doi:10.1261/rna.2248605
Europe PMC | doi

Azzouz TN, Pillai RS, Däpp C, Chari A, Meister G, Kambach C, Fischer U, Schümperli D. (2005)

Toward an assembly line for U7 snRNPs - Interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes.

J Biol Chem 280(41):34435-34440. doi:10.1074/jbc.M505077200
Europe PMC | doi

Pillai RS, Bhattacharyya SN, Artus CG, Zoller T, Cougot N, Basyuk E, Bertrand E, Filipowicz W. (2005)

Inhibition of translational initiation by Let-7 MicroRNA in human cells

Science 309(5740):1573-1576. doi:10.1126/science.1115079
Europe PMC | doi

Xu HZ, Pillai RS, Azzouz TN, Shpargel KB, Kambach C, Hebert MD, Schümperli D, Matera AG. (2005)

The C-terminal domain of coilin interacts with Sm proteins and U snRNPs.

Chromosoma 114(3):155-166. doi:10.1007/s00412-005-0003-y
Europe PMC | doi

Filipowicz W, Jaskiewicz L, Kolb FA, Pillai RS. (2005)

Post-transcriptional gene silencing by siRNAs and miRNAs.

Curr Opin Struct Biol 15(3):331-341. doi:10.1016/j.sbi.2005.05.006
Europe PMC | doi


Pillai RS, Artus CG, Filipowicz W. (2004)

Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis

RNA 10(10):1518-1525. doi:10.1261/rna.7131604
Europe PMC | doi

Schümperli D, Pillai R. (2004)

The special Sm core structure of the U7 snRNP: far-reaching significance of a small nuclear ribonucleoprotein.

Cell Mol Life Sci 61(19-20):2560-2570. doi:10.1007/s00018-004-4190-0
Europe PMC | doi


Pillai RS, Grimmler M, Meister G, Will CL, Lührmann R, Fischer U, Schümperli D. (2003)

Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing.

Genes Dev 17(18):2321-2333. doi:10.1101/gad.274403
Europe PMC | doi


Pillai RS, Will CL, Lührmann R, Schümperli D, Müller B. (2001)

Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein.

EMBO J 20(19):5470-5479. doi:10.1093/emboj/20.19.5470
Europe PMC | doi

Meister G, Bühler D, Pillai R, Lottspeich F, Fischer U. (2001)

A multiprotein complex mediates the ATP-dependent assembly of spliceosomal U snRNPs.

Nat Cell Biol 3(11):945-949. doi:10.1038/ncb1101-945
Europe PMC | doi