Schaffitzel TeamCollaborative Projects

Starting date: 1 December 2011
Duration: 5 years
Total funding: € 12 000 000
Contract no: 277899
Coordinator: Luciano di Croce, CRG Barcelona, Spain
EMBL faculty:
EMBL Grenoble: Christiane Schaffitzel, Imre Berger
EMBL Heidelberg: Christoph Müller
Project web site: www.4dcellfate.eu

The aim of 4DCellFate is to develop a system-wide understanding of how the PRC and NuRD complexes function to control cell fate. 4DCellfate establishes an integrated approach to explore the structure and function of PRC and NuRD, and their interactions with other regulatory factors, nucleic acids, and nucleosomes. Further, the project aims at developing small molecule inhibitors and activators of PRC/NuRD complexes to control chromatin structure with the ultimate objective to directly influence transcriptional profiles, stem cell renewal and differentiation, and cancer.