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Heidelberg, London, 16 February 2017 GSK and EMBL form a new strategic collaboration to enhance understanding of disease and drug mechanisms EMBL and GSK have signed a collaboration agreement to leverage the skills of both organisations to enhance understanding of disease and drug mechanisms and advance early drug discovery. EMBL and GSK will jointly develop and apply cutting edge technologies that will allow the comprehensive characterisation of how a potential new medicine will interact with human biology on a molecular, cellular and organ level to better predict its actions in the human body.
Monterotondo, 9 January 2017 Neural connection keeps instincts in check From fighting the urge to hit someone to resisting the temptation to run off stage instead of giving that public speech, we are often confronted with situations where we have to curb our instincts. Scientists at EMBL have traced exactly which neuronal projections prevent social animals like us from acting out such impulses. The study, published online today in Nature Neuroscience, could have implications for schizophrenia and mood disorders like depression.
- Corriere della Sera , 10 January 2017 Meccanismo in cervello soffoca istinti
- La Repubblica , 10 January 2017 Dalla paura al sesso, ecco come il cervello soffoca gli istinti
Grenoble, 21 December 2016 How flu steals your RNA New work by the Cusack group at EMBL published this week in Nature explains how the influenza virus’ transcription machine interacts with its counterpart in the host cell, offering new possibilities for anti-viral drug design. “We’ve uncovered the details of a mechanism that’s common to all influenza strains, so we believe this could be a good target for developing new flu drugs,” says Stephen Cusack.
Monterotondo, 13 December 2016 Study offers approach to treating pain For many patients with chronic pain, any light touch – even just their clothes touching their skin – can be agony. The Heppenstall lab at EMBL and colleagues have found a possible new avenue for producing painkillers that specifically treat this kind of pain. In a study published online today in eLife, they discovered how the stiffness of our nerve cells influences sensitivity to touch and pain.
Grenoble, 23 November 2016 Toxoplasma’s balancing act explained The parasite Toxoplasma gondii is a silent success. It infects up to 95% of people in many regions of the world, and most of them never know it, due to the parasite’s artful manipulation of its host’s immune response. Toxoplasma keeps the immune response low enough so that it can thrive, but high enough so that its human hosts generally live healthy lives and can incubate parasites. Matthew Bowler and colleagues at EMBL and the Institute for Advanced Biosciences (IAB, an INSERM - CNRS - Université Grenoble-Alpes research centre) have uncovered one of the ways it maintains this balance, in a paper published today in Structure.
Heidelberg, 3 November 2016 Picture Release | Spiral growth This flower-like image shows a plant that is not developing quite right. It comes from a study in which scientists at EMBL and the University of Sydney unearthed the molecular feedback loop that creates the spiral pattern of leaves around a stem. The work is published today in Current Biology.
Heidelberg, 3 October 2016 In pursuit of flat growth in leaves How does a set of plant cells grow from a bump into a flat leaf that can efficiently capture sunlight? In a paper published this week in PNAS, EMBL scientists show how different types of molecules on the top and bottom of a leaf keep each other in check, ensuring the leaf grows flat.
Hamburg, 4 August 2016 Every atom counts Cancer cells are more dependent on a cellular garbage disposal unit – the proteasome – than healthy cells, and cancer therapies take advantage of this dependency. The Schneider group at EMBL Hamburg and colleagues at MPI Göttingen have now succeeded in determining the 3D structure of the human proteasome in unprecedented detail and have deciphered the exact mechanism by which inhibitor drugs block the proteasome. Their surprising results, published in Science, will pave the way to develop more effective treatments.
Heidelberg, 3 August 2016 The force is strong with embryo cells For a cell in an embryo, the secret to becoming part of the baby’s body instead of the placenta is to contract more and carry on dancing, scientists in the Hiiragi and Nédélec labs at EMBL have found. The study, published today in Nature, could one day have implications for assisted reproduction.
Heidelberg, 14 July 2016 How new HIV drugs lock virus in immaturity A new type of HIV drug currently being tested works in an unusual way, scientists in the Molecular Medicine Partnership Unit, a collaboration between EMBL and Heidelberg University Hospital, have found. They also discovered that when the virus became resistant to early versions of these drugs, it did not do so by blocking or preventing their effects, but rather by circumventing them. The study, published online today in Science, presents the most detailed view yet of part of the immature form of HIV.
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