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Heidelberg, 3 October 2016 In pursuit of flat growth in leaves How does a set of plant cells grow from a bump into a flat leaf that can efficiently capture sunlight? In a paper published this week in PNAS, EMBL scientists show how different types of molecules on the top and bottom of a leaf keep each other in check, ensuring the leaf grows flat.
Hamburg, 4 August 2016 Every atom counts Cancer cells are more dependent on a cellular garbage disposal unit – the proteasome – than healthy cells, and cancer therapies take advantage of this dependency. The Schneider group at EMBL Hamburg and colleagues at MPI Göttingen have now succeeded in determining the 3D structure of the human proteasome in unprecedented detail and have deciphered the exact mechanism by which inhibitor drugs block the proteasome. Their surprising results, published in Science, will pave the way to develop more effective treatments.
Heidelberg, 3 August 2016 The force is strong with embryo cells For a cell in an embryo, the secret to becoming part of the baby’s body instead of the placenta is to contract more and carry on dancing, scientists in the Hiiragi and Nédélec labs at EMBL have found. The study, published today in Nature, could one day have implications for assisted reproduction.
Heidelberg, 14 July 2016 How new HIV drugs lock virus in immaturity A new type of HIV drug currently being tested works in an unusual way, scientists in the Molecular Medicine Partnership Unit, a collaboration between EMBL and Heidelberg University Hospital, have found. They also discovered that when the virus became resistant to early versions of these drugs, it did not do so by blocking or preventing their effects, but rather by circumventing them. The study, published online today in Science, presents the most detailed view yet of part of the immature form of HIV.
Heidelberg, 24 June 2016 Impact on EMBL of UK referendum to leave EU Yesterday, the United Kingdom (UK) electorate voted to leave the European Union (EU). The UK’s decision to leave the EU has no direct consequences for the UK’s membership of EMBL. There will be no immediate impact on EMBL as a whole or on EMBL-EBI in particular.
Heidelberg, 28 April 2016 Poo transplants better understood For the first time, scientists studying stool transplants have been able to track which strains of bacteria from a donor take hold in a patient’s gut after a transplant. The team, led by EMBL with collaborators at Wageningen University and the Academic Medical Centre, both in the Netherlands, and the University of Helsinki, Finland found that compatibility between donor and patient likely plays a bigger role in these transplants than previously thought. The study, published today in Science, could help make stool transplants a valid treatment option for more conditions than they are currently applied to.
Heidelberg, 14 April 2016 EMBL scientists reveal structure of nuclear pore’s inner ring It was a 3D puzzle with over 1000 pieces, with only a rather fuzzy outline as a guide. But scientists in the Beck group at EMBL have now put enough pieces in place to see the big picture. In a study published today in Science, they present their latest findings, bringing the nuclear pore complex into focus.
Heidelberg, 30 March 2016 Designing gene therapy Scientists at EMBL have increased the efficiency of a gene-editing tool called Sleeping Beauty, which is showing promise in clinical trials for leukaemia and lymphoma immunotherapies. They made the improvement by determining the 3-dimensional structure of the molecule’s active domain, and using that information to design better versions of this tool. Published today in Nature Communications, the study is likely to lead to further enhancements, ultimately resulting in better patient outcomes.
Heidelberg, 21 March 2016 Mothers and daughters EMBL scientists have observed how an egg cell gets rid of its centrioles – structures that play a crucial role in cell division – to ensure the proper development of the embryo. The study, published today in Journal of Cell Biology, is the first time the whole process has been seen in its entirety, in real time.
Monterotondo, 18 March 2016 Forgetting to learn They say that once you’ve learned to ride a bicycle, you never forget how to do it. But new research suggests that while learning, the brain is actively trying to forget. The study, by the Gross group at EMBL and colleagues at the University Pablo Olavide in Sevilla, Spain, is published today in Nature Communications.
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