Postdoctoral Fellowship Integrative Structural Studies of Peroxisomal Translocon Components and Complexes
Location:Hamburg, Germany
Staff Category:Postdoctoral Fellow
Contract Duration:2 years
Closing Date:15 March 2017
Reference Number:HH_00110

Job Description

The European Molecular Biology Laboratory (EMBL) is one of the highest ranked scientific research organisations in the world. The Headquarters Laboratory is located in Heidelberg (Germany), with additional sites in Grenoble (France), Hamburg (Germany), Hinxton (UK) and Monterotondo (Italy).

The research group of Matthias Wilmanns has a long-standing record in structural biology on research themes that are of medical relevance. Most of our projects require the combined use of different structural biology methods by combined and integrative approaches, generally followed by functional experiments.

Project Outline: The peroxisomal translocon consists of a dynamic multi protein component complex and allows the transport of large, folded and functional target proteins. Whereas the mechanism of target recognition by receptors of the translocon has already been well investigated, less is known about the mechanism of target release into the peroxisomal lumen. The task of the fellowship will be investigate the structure and function of protein factors involved in such release, in the presence of substrates and within the structural framework of the complete translocon. The fellowship is supported by a research consortium, opening plenty of opportunities for interdisciplinary collaboration, exchange and participation at international meetings.

Source of funding: DFG (2 years)

Qualifications and Experience

Applicants should have a PhD in a relevant field, proven record of scientific accomplishments, international experience, scientific ambition and excellent communication skills, and previously demonstrated expertise in relevant structural biology approaches including sample preparation, data acquisition and data analysis. Additional expertise in protein chemistry (molecular biology, heterologous expression, protein purification), biochemistry (purified proteins, cell-based assays) and cell biology (including imaging) would be advantageous.

Application Instructions

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Additional Information

Further comments: This position will be advertised by EMBL. Informal inquiries should be sent to:

EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation.

Please note that appointments on fixed term contracts can be renewed, depending on circumstances at the time of the review.