4D CellFate

4D CellFate

Starting date: 1 December 2011
Duration: 5 years
Total funding: € 12 000 000
Contract no: 277899
Coordinator: Luciano di Croce, CRG Barcelona, Spain
EMBL faculty:
EMBL Grenoble: Christiane Schaffitzel, Imre Berger
EMBL Heidelberg: Christoph Müller
Project web site: www.4dcellfate.eu

The aim of 4DCellFate is to develop a system-wide understanding of how the PRC and NuRD complexes function to control cell fate. 4DCellfate establishes an integrated approach to explore the structure and function of PRC and NuRD, and their interactions with other regulatory factors, nucleic acids, and nucleosomes. Further, the project aims at developing small molecule inhibitors and activators of PRC/NuRD complexes to control chromatin structure with the ultimate objective to directly influence transcriptional profiles, stem cell renewal and differentiation, and cancer.

BioStruct-X

BioStruct-X

Project type: Integrated Infrastructure Initiative (I3), (Grant agreement no: 283570)
Funding organisation: EC, FP7
Project duration: September 2011 – August 2015
Web page: www.biostruct-x.eu
EMBL faculty:
EMBL Hamburg: Dmitri Svergun (coordinator), Matthias Wilmanns, Thomas Schneider, Dmitri Svergun, Victor Lamzin, Rob Meijers, Jochen Müller-Dieckmann
EMBL Grenoble: Stephen Cusack, Darren Hart, Imre Berger, Jose Marquez, Andrew McCarthy, Florent Cipriani
Project aim: The overall objectives of BioStruct-X are:

  • To provide supported transnational access (TNA) to researchers across Europe, based upon scientific excellence of the projects proposed, to leading research services in X-ray based structural biology, including protein production, HTP crystallisation and structural biology-oriented synchrotron radiation beamlines, with applications in macromolecular X-ray crystallography (MX), small angle X-ray scattering (SAXS) and X-ray imaging (XI).
  • To encourage combined and hybrid approaches in structural biology, using facilities from multiple sites, thus enforcing a future concept of integrated structural cell biology.
  • To reinforce TNA to these facilities and to promote the future availability of emerging facilities (XFEL) by an ambitious focused R&D programme, via four joint research activities (JRAs).
  • To provide broad user training and dissemination of new scientific advances via a programme involving both specific TNA facility partners dedicated to these activities and decentralized socalled TID centres at non-facility sites.
  • To liaise with relevant communities, specifically INSTRUCT, other relevant I3 projects, ESUO, and industrial communities.
  • To enforce the goals by the establishment of an efficient and transparent management structure.  

ComplexINC

ComplexINC

Starting date: 1 November 2011
Duration: 4 years
Total funding: € 6 000 000
Contract no: 279039
Coordinator: Imre Berger, EMBL Grenoble
Project web site: www.complexinc.eu

ComplexINC is an international, intersectoral and innovative consortium combining world-leading expertise at European academic research institutions and successful SMEs. Leading technology, innovative drive, competence on the market and direct access to opinion leaders and decision makers are unique assets of ComplexINC. ComplexINC embraces collaboration and co-development and is dedicated to widely disseminate technologies, to catalyse academic and industrial R&D in Europe and beyond.

FINOVI

FINOVI

Project type: Post doctoral grant on respiratory infections
Funding organisation: Fond innovation and infectiologie (Finovi)
Project duration: September 2010 - March 2012
Webpage: www.finovi.org/fr:realisations:projets_finances
EMBL faculty: Darren Hart
Project aim: To understand the role of mutations in the influenza viral polymerase in host adaptation.

FLUPHARM

FLUPHARM

Project type: Collaborative project (Grant agreement nr. 259751)
Funding organisation: EC, FP7
Project duration: November 2010 - May 2014
Web page: www.flupharm.eu
EMBL faculty: Stephen Cusack
Project aim: The project has two strategic objectives To identify new drugs against influenza A viruses, targeting the viral polymerase To continue efforts to solve the atomic structure of the influenza virus polymerase protein complex

HOLOTRANS

HOLOTRANS

Project type: Research collaborative project on methods in life sciences
Funding organisation: Baden-Württemberg Stiftung
Project duration: January 2010 – December 2012
EMBL faculty: Christiane Schaffitzel
Project aim: To develop new methods for the characterization of membrane proteins using electron microscopy. The project studies a protein complex, which is a drug target involved in supplying energy to cells.

P-CUBE

P-CUBE

Project type: I3 Research Infrastructures
Funding organisation: EC, FP7
Project duration: April 2009 – March 2013
Webpage: www.p-cube.eu
EMBL faculty:
EMBL Heidelberg: Christoph Müller
EMBL Hamburg: Matthias Wilmanns, Jochen Müller-Dieckmann
EMBL Grenoble: Stephen Cusack, Darren Hart, Imre Berger, Josan Marquez
Project aim: P-CUBE (Infrastructure for Protein Production Platforms) is the first project within the Seventh Framework Program of the EU that brings together research, networking and service activities. The program offers exciting cutting edge technologies in contemporary structural biology and provides a more general access to European users to the most advanced techniques in cloning, expression, protein characterisation and crystallisation free of charge. It is also the philosophy of P-CUBE to share expertise between the different partner laboratories in order to improve technologies and standardize procedures, with the ultimate aim of disseminating this expertise throughout Europe. World leading European experts in the field of protein expression and production technologies from the University of Zurich, the University of Oxford and the European Molecular Biology Lab share expertise, equipment and their know-how to applicants to ensure smooth workflow.

piRmachines

piRmachines

Project type: Jeune chercheur grant
Funding organisation: Agence nationale de la recherche (ANR)
Project duration: November 2009 - November 2012
EMBL faculty: Ramesh Pillai
Project aim: Animal germ cells express a specialised class of ~30 nt small non-coding RNAs called piwi-interacting RNAs (piRNAs), which help protect genomic stability by silencing transposons. This project aims to understand how such small piRNA are made and how they work in cells.

Pisilence

Pisilence

Project type: Starting grant
Funding organisation: European Research Council (ERC)
Project duration: January 2011 - January 2016
EMBL faculty: Ramesh Pillai
Project aim: To identify cellular factors involved in the production and function of germ-line small RNA by using large scale screening approaches.

TFIID complexes

TFIID complexes

Project type: Projet blanc
Funding organisation: Agence nationale de la recherche (ANR)
Project duration: September 2009 - September 2012
EMBL faculty: Imre Berger
Project aim: To determine the molecular basis of transcription initiation in Eukaryotes.