Seminar Colour Guide:              
External Faculty Speaker
Tuesday, 24 September 2019, 11:00Add to calendarCRYO-EM AND X-RAY FREE ELECTRON LASER ENABLED STRUCTURE BASED DRUG DISCOVERY ON CHALLENGING MEMBRANE PROTEIN TARGETSProf. Dr. Michael Hennig, CEO, leadXpro AG, Villigen, SwitzerlandHost: Jose Antonio MarquezEMBL Seminar Room, EMBL Grenoble
Abstract:
BIOGRAPHY
Michael Hennig studied Physics and Biochemistry, received the Ph.D. in structural biology at EMBL Hamburg, and the Charité, Humboldt University Berlin, Germany. It followed two years postdoc work at the Biozentrum, University of Basel, Switzerland. He is author of more than 80 scientific peer reviewed paper and, since 2011, guest professor in structural biology at the University of Basel. He worked 20 years in pharmaceutical industry at Roche, Basel, Switzerland in various positions and finally was Global Head and Principle Leader of discovery technologies with responsibility for structure-based drug discovery, protein science, assay development and HTS, Roche corporate compound library, stem cell platform and analytical physical methods. In 2015, he co-founded leadXpro, a corporation dedicated to structure-based drug discovery for membrane protein targets (GPCR s, Ion-channels, Transporter) and utilizing most advanced technologies such as the X-ray free electron laser (at PSI, SwissFEL) and cryo-electron microscopy (at University of Basel, cryo-EM).


Title: CRYO-EM AND X-RAY FREE ELECTRON LASER ENABLED STRUCTURE BASED DRUG DISCOVERY ON CHALLENGING MEMBRANE PROTEIN TARGETS


Name: Michael Hennig

leadXpro AG, PARK INNOVAARE, 5234 Villigen, Switzerland

ABSTRACT

Due to their central importance in many physiological processes, membrane proteins are drug targets for around 60% of all approved drugs. Structure based drug discovery on soluble proteins is managed well within the project timelines and portfolio changes in pharmaceutical industry, but transmembrane proteins remain a significant challenge because of their difficulty to be expressed, purified and made them work for full exploration in structure based drug design and high resolution three dimensional structure of complexes with potential drug molecules.
Examples will include the X-ray structure determination of the chemokine receptor CCR2, an emerging target for inflammation, arthritis and oncology by serial X-ray crystallography. Here we explore structural details of ligand binding at the orthosteric and allosteric binding sites to address challenges on drug efficacy and specificity.
X-ray free electron lasers give more physiologically relevant data on protein flexibility at the ligand binding site. Femtosecond X-ray pulses enable monitoring and capturing of dynamic processes of ligand binding and associated conformational changes with great impact to the design of candidate drug compounds.
Furthermore, high resolution cryo-EM structures show increasing impact in drug design due to advances in feasibility of proteins as well as structural resolution. Presentation examples include an ion channel with small molecule agonist as well as a high resolution transporter protein structure validated as antibiotics drug target.
External Faculty Speaker
Monday, 14 October 2019, 10:30Add to calendarDEAD-box ATPases are global regulators of phase-separated organelles.Dr Maria Hondele, Institute of Biochemistry, ETH Zurich,, SwitzerlandHost: Eva KowalinskiEMBL Seminar Room
External Faculty Speaker
Tuesday, 15 October 2019, 11:00Add to calendarTo be announcedDr Ling-Ling Chen, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, ChinaHost: Wojciech GalejEMBL Seminar Room, EMBL Grenoble
External Faculty Speaker
Tuesday, 12 November 2019, 11:00Add to calendarTo be announced Sebastian Guettler, ICR London, United KingdomHost: Wojciech GalejEMBL Seminar Room, EMBL Grenoble
Science and Society
Friday, 15 November 2019, 14:00Add to calendarNo More Second-Class Scientists: Why Supporting Great Scientists Worldwide is Key to Our FutureNina Dudnik, MilliporeSigma, USAHost: Andrew Mc CarthyIBS Seminar Room, EMBL Grenoble
External Faculty Speaker
Thursday, 5 December 2019, 11:00Add to calendarTo be announcedSilvestro Conticello, Institute for the Study and Prevention of Cancer, ItalyHost: Eva KowalinskiEMBL Seminar Room, EMBL Grenoble