EMBL Grenoble, 71 avenue des Martyrs, CS 90181, 38042 Grenoble Cedex 9, France
PhD 1976, Imperial College, London, UK.
Postdoctoral work at EMBL Grenoble.
Staff scientist at EMBL Grenoble 1980-1989.
Group Leader, Senior Scientist and Head of Outstation since 1989.
ERC Advanced Investigator.
Fellow of the Royal Society.
Total: 189 publication(s)
Seiradake E, Cusack S. (2005)
Crystal structure of enteric adenovirus serotype 41 short fiber head
Tukalo M, Yaremchuk A, Fukunaga R, Yokoyama S, Cusack S. (2005)
The crystal structure of leucyl-tRNA synthetase complexed with tRNALeu in the post-transfer-editing conformation
Tarbouriech N, Buisson M, Seigneurin JM, Cusack S, Burmeister WP. (2005)
The monomeric dUTPase from Epstein-Barr virus mimics trimeric dUTPases
Worch R, Niedzwiecka A, Stepinski J, Mazza C, Jankowska-Anyszka M, Darzynkiewicz E, Cusack S, Stolarski R. (2005)
Specificity of recognition of mRNA 5' cap by human nuclear cap-binding complex
Backe PH, Messias AC, Ravelli RB, Sattler M, Cusack S. (2005)
X-ray crystallographic and NMR studies of the third KH domain of hnRNP K in complex with single-stranded nucleic acids
Fabry CM, Rosa-Calatrava M, Conway JF, Zubieta C, Cusack S, Ruigrok RW, Schoehn G. (2005)
A quasi-atomic model of human adenovirus type 5 capsid
Cusack S. (2005)
Adenovirus complex structures
Musier-Forsyth K, Burke B, Cusack, S. (2005)
In: Ibba M, Francklyn C, Cusack S (eds.), Aminoacyl-tRNA Synthetases. Intelligence Unit. Landes Bioscience. pp 149-161.
Weygand-Durasevic I, Cusack S. (2005)
In: Ibba M, Francklyn C, Cusack S (eds.), Aminoacyl-tRNA Synthetases. Intelligence Unit. Landes Bioscience. pp 177-192.
Worch R, Niedzwiecka A, Stepinski J, Jankowska-Anyszka M, Mazza C, Darzynkiewicz E, Cusack S, Stolarski R. (2005)
Significance of the first transcribed nucleoside of capped RNA for ligand-induced folding of the cap-binding complex
J Phys Condens Matter 17(18):S1495-S1502.
Worch R, Stepinski J, Niedzwiecka A, Jankowska-Anyszka M, Mazza C, Cusack S, Stolarski R, Darzynkiewicz E. (2005)
Novel way of capping mRNA trimer and studies of its interaction with human nuclear cap-binding complex
Paper presented at the 16th International Roundtable of the International-Society-for-Nucleosides-Nucleotides-and-Nucleic-Acids (IS3NA), Minneapolis, MN, SEP 12-16, 2004.Nucleosides Nucleotides Nucleic Acids 24(5-7):1131-1134. doi: 10.1081/ncn-200061898
Europe PMC | doi
Zubieta C, Schoehn G, Chroboczek J, Cusack S. (2005)
The structure of the human adenovirus 2 penton
Burmeister WP, Guilligay D, Cusack S, Wadell G, Arnberg N. (2004)
Crystal structure of species D adenovirus fiber knobs and their sialic acid binding sites
Backe PH, Ravelli RB, Garman E, Cusack S. (2004)
Crystallization, microPIXE and preliminary crystallographic analysis of the complex between the third KH domain of hnRNP K and single-stranded DNA
Kadlec J, Izaurralde E, Cusack S. (2004)
The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3
Huck L, Scherrer A, Terzi L, Johnson AE, Bernstein HD, Cusack S, Weichenrieder O, Strub K. (2004)
Conserved tertiary base pairing ensures proper RNA folding and efficient assembly of the signal recognition particle Alu domain
Kobayashi T, Nureki O, Ishitani R, Yaremchuk A, Tukalo M, Cusack S, Sakamoto K, Yokoyama S. (2003)
Structural basis for orthogonal tRNA specificities of tyrosyl-tRNA synthetases for genetic code expansion
Lincecum TL Jr, Tukalo M, Yaremchuk A, Mursinna RS, Williams AM, Sproat BS, Van Den Eynde W, Link A, Van Calenbergh S, Grøtli M, Martinis SA, Cusack S. (2003)
Structural and mechanistic basis of pre- and posttransfer editing by leucyl-tRNA synthetase
Mazza C, Segref A, Mattaj IW, Cusack S. (2002)
Co-crystallization of the human nuclear cap-binding complex with a m7GpppG cap analogue using protein engineering
Zeth K, Ravelli RB, Paal K, Cusack S, Bukau B, Dougan DA. (2002)
Structural analysis of the adaptor protein ClpS in complex with the N-terminal domain of ClpA
Mazza C, Segref A, Mattaj IW, Cusack S. (2002)
Large-scale induced fit recognition of an m(7)GpppG cap analogue by the human nuclear cap-binding complex
Yaremchuk A, Kriklivyi I, Tukalo M, Cusack S. (2002)
Class I tyrosyl-tRNA synthetase has a class II mode of cognate tRNA recognition
Zeth K, Dougan DA, Cusack S, Bukau B, Ravelli RB. (2002)
Crystallization and preliminary X-ray analysis of the Escherichia coli adaptor protein ClpS, free and in complex with the N-terminal domain of ClpA
Myers CA, Kuhla B, Cusack S, Lambowitz AM. (2002)
tRNA-like recognition of group I introns by a tyrosyl-tRNA synthetase
Wild K, Weichenrieder O, Strub K, Sinning I, Cusack S. (2002)
Towards the structure of the mammalian signal recognition particle
Mitraki A, Raaij M, Ruigrok R, Cusack S, Hernandez J-F, Luckey M. (2002)
Structure, folding and assembly of adenovirus fibers
Wild K, Sinning I, Cusack S. (2001)
Crystal structure of an early protein-RNA assembly complex of the signal recognition particle
Mazza C, Ohno M, Segref A, Mattaj IW, Cusack S. (2001)
Crystal structure of the human nuclear cap binding complex
Durmort C, Stehlin C, Schoehn G, Mitraki A, Drouet E, Cusack S, Burmeister WP. (2001)
Structure of the fiber head of Ad3, a non-CAR-binding serotype of adenovirus
Yaremchuk A, Tukalo M, Grøtli M, Cusack S. (2001)
A succession of substrate induced conformational changes ensures the amino acid specificity of Thermus thermophilus prolyl-tRNA synthetase: comparison with histidyl-tRNA synthetase
Weichenrieder O, Stehlin C, Kapp U, Birse DE, Timmins PA, Strub K, Cusack S. (2001)
Hierarchical assembly of the Alu domain of the mammalian signal recognition particle
Lortat-Jacob H, Chouin E, Cusack S, van Raaij MJ. (2001)
Kinetic analysis of adenovirus fiber binding to its receptor reveals an avidity mechanism for trimeric receptor-ligand interactions
Leissner P, Legrand V, Schlesinger Y, Hadji DA, van Raaij M, Cusack S, Pavirani A, Mehtali M. (2001)
Influence of adenoviral fiber mutations on viral encapsidation, infectivity and in vivo tropism
van Raaij MJ, Chouin E, van der Zandt H, Bergelson JM, Cusack S. (2000)
Dimeric structure of the coxsackievirus and adenovirus receptor D1 domain at 1.7 A resolution
Weichenrieder O, Wild K, Strub K, Cusack S. (2000)
Structure and assembly of the Alu domain of the mammalian signal recognition particle
Monaco-Malbet S, Berthet-Colominas C, Novelli A, Battaï N, Piga N, Cheynet V, Mallet F, Cusack S. (2000)
Mutual conformational adaptations in antigen and antibody upon complex formation between an Fab and HIV-1 capsid protein p24
Yaremchuk A, Cusack S, Tukalo M. (2000)
Crystal structure of a eukaryote/archaeon-like protyl-tRNA synthetase and its complex with tRNAPro(CGG)
Cusack S, Yaremchuk A, Tukalo M. (2000)
The 2 A crystal structure of leucyl-tRNA synthetase and its complex with a leucyl-adenylate analogue
Yaremchuk A, Cusack S, Gudzera O, Grøtli M, Tukalo M. (2000)
Crystallization and preliminary crystallographic analysis of Thermus thermophilus leucyl-tRNA synthetase and its complexes with leucine and a non-hydrolysable leucyl-adenylate analogue
Yaremchuk A, Cusack S, Tukalo M. (2000)
Crystallization and preliminary X-ray diffraction analysis of Thermus thermophilus prolyl-tRNA synthetase
Yaremchuk A, Kriklivyi I, Cusack S, Tukalo M. (2000)
Improved crystals of Thermus thermophilus prolyl-tRNA synthetase complexed with cognate tRNA obtained by crystallization from precipitate
Wild K, Weichenrieder O, Leonard GA, Cusack S. (1999)
The 2 A structure of helix 6 of the human signal recognition particle RNA
Perrakis A, Cipriani F, Castagna JC, Claustre L, Burghammer M, Riekel C, Cusack S. (1999)
Protein microcrystals and the design of a microdiffractometer: current experience and plans at EMBL and ESRF/ID13
van Raaij MJ, Mitraki A, Lavigne G, Cusack S. (1999)
A triple beta-spiral in the adenovirus fibre shaft reveals a new structural motif for a fibrous protein
van Raaij MJ, Louis N, Chroboczek J, Cusack S. (1999)
Structure of the human adenovirus serotype 2 fiber head domain at 1.5 A resolution
Berthet-Colominas C, Monaco S, Novelli A, Sibaï G, Mallet F, Cusack S. (1999)
Head-to-tail dimers and interdomain flexibility revealed by the crystal structure of HIV-1 capsid protein (p24) complexed with a monoclonal antibody Fab
Cusack S. (1999)
Shilton B, Svergun DI, Volkov VV, Koch MH, Cusack S, Economou A. (1998)
Escherichia coli SecA shape and dimensions
Cusack S, Belrhali H, Bram A, Burghammer M, Perrakis A, Riekel C. (1998)
Small is beautiful: protein micro-crystallography
Berthet-Colominas C, Seignovert L, Härtlein M, Grotli M, Cusack S, Leberman R. (1998)
The crystal structure of asparaginyl-tRNA synthetase from Thermus thermophilus and its complexes with ATP and asparaginyl-adenylate: the mechanism of discrimination between asparagine and aspartic acid
Cusack S, Yaremchuk A, Krikliviy I, Tukalo M. (1998)
tRNA(Pro) anticodon recognition by Thermus thermophilus prolyl-tRNA synthetase
Cusack S, Yaremchuk Y, Tukalo M. (1998)
tRNA recognition by aminoacyl-tRNA synthetases
In: Eggleston DS, Prescott CD, Pearson ND (eds.), The Many Faces of RNA. Academic Press, London. pp 55-65.doi: 10.1016/B978-012233210-4/50005-0
Weichenrieder O, Kapp U, Cusack S, Strub K. (1997)
Identification of a minimal Alu RNA folding domain that specifically binds SRP9/14
Birse DE, Kapp U, Strub K, Cusack S, Aberg A. (1997)
The crystal structure of the signal recognition particle Alu RNA binding heterodimer, SRP9/14
Aberg A, Yaremchuk A, Tukalo M, Rasmussen B, Cusack S. (1997)
Crystal structure analysis of the activation of histidine by Thermus thermophilus histidyl-tRNA synthetase
Cusack S, Yaremchuk A, Tukalo M. (1996)
The crystal structures of T. thermophilus lysyl-tRNA synthetase complexed with E. coli tRNA(Lys) and a T. thermophilus tRNA(Lys) transcript: anticodon recognition and conformational changes upon binding of a lysyl-adenylate analogue
EMBO J. 15(22):6321-6334.
Cusack S, Yaremchuk A, Tukalo M. (1996)
The crystal structure of the ternary complex of T.thermophilus seryl-tRNA synthetase with tRNA(Ser) and a seryl-adenylate analogue reveals a conformational switch in the active site
EMBO J. 15(11):2834-2842.
Kawashima T, Berthet-Colominas C, Wulff M, Cusack S, Leberman R. (1996)
The structure of the Escherichia coli EF-Tu.EF-Ts complex at 2.5 A resolution
Yaremchuk AD, Cusack S, Aberg A, Gudzera O, Kryklivyi I, Tukalo M. (1995)
Crystallization of Thermus thermophilus histidyl-tRNA synthetase and its complex with tRNAHis
Belrhali H, Yaremchuk A, Tukalo M, Berthet-Colominas C, Rasmussen B, Bösecke P, Diat O, Cusack S. (1995)
The structural basis for seryl-adenylate and Ap4A synthesis by seryl-tRNA synthetase
Yaremchuk AD, Krikliviy IA, Cusack S, Tukalo MA. (1995)
Cocrystallization of lysyl-tRNA synthetase from Thermus thermophilus with its cognate tRNAlys and with Escherichia coli tRNAlys
Baudin F, Bach C, Cusack S, Ruigrok RW. (1994)
Structure of influenza virus RNP. I. Influenza virus nucleoprotein melts secondary structure in panhandle RNA and exposes the bases to the solvent
EMBO J. 13(13):3158-3165.
Biou V, Yaremchuk A, Tukalo M, Cusack S. (1994)
The 2.9 A crystal structure of T. thermophilus seryl-tRNA synthetase complexed with tRNA(Ser)
Elster C, Fourest E, Baudin F, Larsen K, Cusack S, Ruigrok RW. (1994)
A small percentage of influenza virus M1 protein contains zinc but zinc does not influence in vitro M1-RNA interaction
Burmeister WP, Baudin F, Cusack S, Ruigrok RW. (1993)
Comparison of structure and sequence of influenza B/Yamagata and B/Beijing neuraminidases shows a conserved "head" but much greater variability in the "stalk" and NB protein
Kidd AH, Chroboczek J, Cusack S, Ruigrok RW. (1993)
Adenovirus type 40 virions contain two distinct fibers
Burmeister WP, Ruigrok RW, Cusack S. (1992)
The 2.2 A resolution crystal structure of influenza B neuraminidase and its complex with sialic acid
Cusack S, Berthet-Colominas C, Härtlein M, Nassar N, Leberman R. (1990)
A second class of synthetase structure revealed by X-ray analysis of Escherichia coli seryl-tRNA synthetase at 2.5 A
Doster W, Cusack S, Petry W. (1990)
Dynamic instability of liquidlike motions in a globular protein observed by inelastic neutron scattering
Cusack S, Jacrot B, Leberman R, May R, Timmins P, Zaccai G. (1989)
Doster W, Cusack S, Petry W. (1989)
Dynamical transition of myoglobin revealed by inelastic neutron scattering
Cusack S, Smith J, Finney J, Tidor B, Karplus M. (1988)
Inelastic neutron scattering analysis of picosecond internal protein dynamics. Comparison of harmonic theory with experiment.
Weis W, Brown JH, Cusack S, Paulson JC, Skehel JJ, Wiley DC. (1988)
Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid.
Smith J, Cusack S, Poole P, Finney J. (1987)
Direct measurement of hydration-related dynamic changes in lysozyme using inelastic neutron scattering spectroscopy.
Leberman R, Berthet-Colominas C, Cusack S, Härtlein M. (1987)
Crystals of seryl-tRNA synthetase from Escherichia coli. Preliminary crystallographic data.
Ruigrok RW, Wrigley NG, Calder LJ, Cusack S, Wharton SA, Brown EB, Skehel JJ. (1986)
Electron microscopy of the low pH structure of influenza virus haemagglutinin.
EMBO J. 5(1):41-49.
Cusack S, Ruigrok RW, Krygsman PC, Mellema JE. (1985)
Structure and composition of influenza virus. A small-angle neutron scattering study.
Cusack S, Jésior JC. (1985)
Three-dimensional molecular shape determination from a limited number of projections.
Hewat EA, Cusack S, Ruigrok RW, Verwey C. (1984)
Low resolution structure of the influenza C glycoprotein determined by electron microscopy.
Cusack S, Lees S. (1984)
Variation of longitudinal acoustic velocity at gigahertz frequencies with water content in rat-tail tendon fibers.
Cusack S. (1984)
Neutron scattering studies of virus structure.
Basic Life Sci. 27:173-188.
Engelman DM, Dianoux AJ, Cusack S, Jacrot B. (1984)
Inelastic neutron scattering studies of hexokinase in solution.
Basic Life Sci. 27:365-380.
Cusack S, Oostergetel GT, Krijgsman PC, Mellema JE. (1983)
Structure of the Top a-t component of alfalfa mosaic virus. A non-icosahedral virion.
Oostergetel GT, Mellema JE, Cusack S. (1983)
Solution scattering study on the structure of alfalfa mosaic virus strain VRU.
Jacrot B, Cusack S, Dianoux AJ, Engelman DM. (1982)
Inelastic neutron scattering analysis of hexokinase dynamics and its modification on binding of glucose.
Mellema JE, Andree PJ, Krygsman PC, Kroon C, Ruigrok RW, Cusack S, Miller A, Zulauf M. (1981)
Structural investigations of influenza B virus.
Oostergetel GT, Krijgsman PC, Mellema JE, Cusack S, Miller A. (1981)
Evidence for the absence of swelling of alfalfa mosaic virions.
Cusack S, Miller A, Krijgsman PC, Mellema JE. (1981)
An investigation of the structure of alfalfa mosaic virus by small-angle neutron scattering.
Cusack S, Miller A. (1979)
Determination of the elastic constants of collagen by Brillouin light scattering.