EMBL Grenoble, 71 avenue des Martyrs, CS 90181, 38042 Grenoble Cedex 9, France


  • PhD 2013, University of Cambridge, UK.
    Postdoctoral research at MRC Laboratory of Molecular Biology, Cambridge, UK.
    Group leader at EMBL since 2016.


Total: 10 publication(s)


Galej WP, Toor N, Newman AJ, Nagai K. (2018)

Molecular Mechanism and Evolution of Nuclear Pre-mRNA and Group II Intron Splicing: Insights from Cryo-Electron Microscopy Structures.

Chem Rev 118(8) doi: 10.1021/acs.chemrev.7b00499
Europe PMC | doi


Wilkinson ME, Fica SM, Galej WP, Norman CM, Newman AJ, Nagai K. (2017)

Postcatalytic spliceosome structure reveals mechanism of 3'-splice site selection.

Science 358(6368) doi: 10.1126/science.aar3729
Europe PMC | doi

Fica SM, Oubridge C, Galej WP, Wilkinson ME, Bai XC, Newman AJ, Nagai K. (2017)

Structure of a spliceosome remodelled for exon ligation.

Nature 542(7641):377-380. doi: 10.1038/nature21078
Europe PMC | doi


Galej WP, Wilkinson ME, Fica SM, Oubridge C, Newman AJ, Nagai K. (2016)

Cryo-EM structure of the spliceosome immediately after branching.

Nature 537(7619) doi: 10.1038/nature19316
Europe PMC | doi

Nguyen TH, Galej WP, Bai XC, Oubridge C, Newman AJ, Scheres SH, Nagai K. (2016)

Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 A resolution.

Nature 530(7590):298-302. doi: 10.1038/nature16940
Europe PMC | doi

Nguyen TH, Galej WP, Fica SM, Lin PC, Newman AJ, Nagai K. (2016)

CryoEM structures of two spliceosomal complexes: starter and dessert at the spliceosome feast.

Curr. Opin. Struct. Biol. 36:48-57. doi: 10.1016/j.sbi.2015.12.005
Europe PMC | doi


Nguyen TH, Galej WP, Bai XC, Savva CG, Newman AJ, Scheres SH, Nagai K. (2015)

The architecture of the spliceosomal U4/U6.U5 tri-snRNP.

Nature 523(7558):47-52. doi: 10.1038/nature14548
Europe PMC | doi


Galej WP, Nguyen TH, Newman AJ, Nagai K. (2014)

Structural studies of the spliceosome: zooming into the heart of the machine.

Curr. Opin. Struct. Biol. 25:57-66. doi: 10.1016/j.sbi.2013.12.002
Europe PMC | doi


Nguyen TH, Li J, Galej WP, Oshikane H, Newman AJ, Nagai K. (2013)

Structural basis of Brr2-Prp8 interactions and implications for U5 snRNP biogenesis and the spliceosome active site.

Structure 21(6):910-919. doi: 10.1016/j.str.2013.04.017
Europe PMC | doi

Galej WP, Oubridge C, Newman AJ, Nagai K. (2013)

Crystal structure of Prp8 reveals active site cavity of the spliceosome.

Nature 493(7434):638-643. doi: 10.1038/nature11843
Europe PMC | doi