EMBL Grenoble, 71 avenue des Martyrs, CS 90181, 38042 Grenoble Cedex 9, France

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  • PhD 1997, University of Valencia, Spain.
    Postdoctoral research at EMBL.
    Staff Scientist at EMBL Grenoble since 2003.
    Team Leader since 2005.
    Head of Crystallisation Facility since 2012.


Total: 36 publication(s)


Fernández I, Cornaciu I, Del Carmen Carrica M, Uchikawa E, Hoffmann G, Sieira R, Márquez JA, Goldbaum FA. (2017)

Three-dimensional structure of full-length NtrX, an unusual member of the NtrC family of response regulators.

J. Mol. Biol. doi: 10.1016/j.jmb.2016.12.022
Europe PMC | doi

Kaczmarska Z, Ortega E, Goudarzi A, Huang H, Kim S, Márquez JA, Zhao Y, Khochbin S, Panne D. (2017)

Structure of p300 in complex with acyl-CoA variants

Nat. Chem. Biol. 13(1):21-29. doi: 10.1038/nchembio.2217
Europe PMC | doi


Mkaouar H, Akermi N, Mariaule V, Boudebbouze S, Gaci N, Szukala F, Pons N, Marquez J, Gargouri A, Maguin E, Rhimi M. (2016)

Siropins, novel serine protease inhibitors from gut microbiota acting on human proteases involved in inflammatory bowel diseases.

Microb. Cell Fact. 15(1):201. doi: 10.1186/s12934-016-0596-2
Europe PMC | doi

Zander U, Hoffmann G, Cornaciu I, Marquette JP, Papp G, Landret C, Seroul G, Sinoir J, Röwer M, Felisaz F, Rodriguez-Puente S, Mariaule V, Murphy P, Mathieu M, Cipriani F, Márquez JA. (2016)

Automated harvesting and processing of protein crystals through laser photoablation.

Acta Crystallogr D Struct Biol 72(Pt 4):454-466. doi: 10.1107/s2059798316000954
Europe PMC | doi

Diaz M, Sanchez-Barrena MJ, Gonzalez-Rubio JM, Rodriguez L, Fernandez D, Antoni R, Yunta C, Belda-Palazon B, Gonzalez-Guzman M, Peirats-Llobet M, Menendez M, Boskovic J, Marquez JA, Rodriguez PL, Albert A. (2016)

Calcium-dependent oligomerization of CAR proteins at cell membrane modulates ABA signaling

P NATL ACAD SCI USA 113(3):E396-E405. doi: 10.1073/pnas.1512779113
Europe PMC | doi


Myrum C, Baumann A, Bustad HJ, Flydal MI, Mariaule V, Alvira S, Cuellar J, Haavik J, Soule J, Valpuesta JM, Marquez JA, Martinez A, Bramham CR. (2015)

Arc is a flexible modular protein capable of reversible self-oligomerization

Biochem. J. 468:145-158. doi: 10.1042/BJ20141446
Europe PMC | doi


Rodriguez L, Gonzalez-Guzman M, Diaz M, Rodrigues A, Izquierdo-Garcia AC, Peirats-Llobet M, Fernandez MA, Antoni R, Fernandez D, Marquez JA, Mulet JM, Albert A, Rodriguez PL. (2014)

C2-Domain Abscisic Acid-Related Proteins Mediate the Interaction of PYR/PYL/RCAR Abscisic Acid Receptors with the Plasma Membrane and Regulate Abscisic Acid Sensitivity in Arabidopsis.

Plant Cell doi: 10.1105/tpc.114.129973
Europe PMC | doi

Keller MA, Zander U, Fuchs JE, Kreutz C, Watschinger K, Mueller T, Golderer G, Liedl KR, Ralser M, Kräutler B, Werner ER, Marquez JA. (2014)

A gatekeeper helix determines the substrate specificity of Sjogren-Larsson Syndrome enzyme fatty aldehyde dehydrogenase

Nat Commun 5:Article No:4439. doi: 10.1038/ncomms5439
Europe PMC | doi

Mariaule V, Dupeux F, Márquez JA. (2014)

Estimation of crystallization likelihood through a fluorimetric thermal stability assay

Methods Mol. Biol. 1091:189-195. doi: 10.1007/978-1-62703-691-7_13
Europe PMC | doi

Márquez JA, Cipriani F. (2014)

CrystalDirect™: a novel approach for automated crystal harvesting based on photoablation of thin films

In: Yu Wai Chen, Structural Genomics, vol 1091. Humana Press. pp 197-203.Methods Mol. Biol. 1091:197-203. doi: 10.1007/978-1-62703-691-7_14
Europe PMC | doi


Casañal A, Zander U, Muñoz C, Dupeux F, Luque I, Botella MA, Schwab W, Valpuesta V, Marquez JA. (2013)

The strawberry pathogenesis-related 10 (PR-10) Fra a proteins control flavonoid biosynthesis by binding to metabolic intermediates

J. Biol. Chem. 288(49):35322-35332. doi: 10.1074/jbc.m113.501528
Europe PMC | doi

Casañal A, Zander U, Dupeux F, Valpuesta V, Marquez JA. (2013)

Purification, crystallization and preliminary X-ray analysis of the strawberry allergens Fra a 1E and Fra a 3 in the presence of catechin

Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 69(Pt 5):510-514. doi: 10.1107/s1744309113006945
Europe PMC | doi

Gueneau E, Dherin C, Legrand P, Tellier-Lebegue C, Gilquin B, Bonnesoeur P, Londino F, Quemener C, Le Du MH, Márquez JA, Moutiez M, Gondry M, Boiteux S, Charbonnier JB. (2013)

Structure of the MutLα C-terminal domain reveals how Mlh1 contributes to Pms1 endonuclease site

Nat. Struct. Mol. Biol. 20(4):461-468. doi: 10.1038/nsmb.2511
Europe PMC | doi


Cipriani F, Röwer M, Landret C, Zander U, Felisaz F, Márquez JA. (2012)

CrystalDirect: a new method for automated crystal harvesting based on laser-induced photoablation of thin films

Acta Crystallogr. D Biol. Crystallogr. 68(Pt 10):1393-1399. doi: 10.1107/s0907444912031459
Europe PMC | doi

Santiago J, Dupeux F, Betz K, Antoni R, Gonzalez-Guzman M, Rodriguez L, Márquez JA, Rodriguez PL. (2012)

Structural insights into PYR/PYL/RCAR ABA receptors and PP2Cs

Plant Sci. 182:3-11. doi: 10.1016/j.plantsci.2010.11.014
Europe PMC | doi


Dupeux F, Röwer M, Seroul G, Blot D, Márquez JA. (2011)

A thermal stability assay can help to estimate the crystallization likelihood of biological samples

Acta Crystallogr. D Biol. Crystallogr. 67(Pt 11):915-919. doi: 10.1107/s0907444911036225
Europe PMC | doi

Dupeux F, Santiago J, Betz K, Twycross J, Park SY, Rodriguez L, Gonzalez-Guzman M, Jensen MR, Krasnogor N, Blackledge M, Holdsworth M, Cutler SR, Rodriguez PL, Márquez JA. (2011)

A thermodynamic switch modulates abscisic acid receptor sensitivity

EMBO J. 30(20):4171-4184. doi: 10.1038/emboj.2011.294
Europe PMC | doi

Ropars V, Drevet P, Legrand P, Baconnais S, Amram J, Faure G, Márquez JA, Piétrement O, Guerois R, Callebaut I, Le Cam E, Revy P, de Villartay JP, Charbonnier JB. (2011)

Structural characterization of filaments formed by human Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA end-joining

Proc. Natl. Acad. Sci. U.S.A. 108(31):12663-12668. doi: 10.1073/pnas.1100758108
Europe PMC | doi

Dupeux F, Antoni R, Betz K, Santiago J, Gonzalez-Guzman M, Rodriguez L, Rubio S, Park SY, Cutler SR, Rodriguez PL, Márquez JA. (2011)

Modulation of abscisic acid signaling in vivo by an engineered receptor-insensitive protein phosphatase type 2C allele

Plant Physiol. 156(1):106-116. doi: 10.1104/pp.110.170894
Europe PMC | doi

Domanska K, Vanderhaegen S, Srinivasan V, Pardon E, Dupeux F, Marquez JA, Giorgetti S, Stoppini M, Wyns L, Bellotti V, Steyaert J. (2011)

Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic beta2-microglobulin variant

Proc. Natl. Acad. Sci. U.S.A. 108(4):1314-1319. doi: 10.1073/pnas.1008560108
Europe PMC | doi


Santiago J, Dupeux F, Round A, Antoni R, Park SY, Jamin M, Cutler SR, Rodriguez PL, Márquez JA. (2009)

The abscisic acid receptor PYR1 in complex with abscisic acid

Nature 462(7273):665-668. doi: 10.1038/nature08591
Europe PMC | doi

Santiago J, Rodrigues A, Saez A, Rubio S, Antoni R, Dupeux F, Park SY, Márquez JA, Cutler SR, Rodriguez PL. (2009)

Modulation of drought resistance by the abscisic acid receptor PYL5 through inhibition of clade A PP2Cs

Plant J. 60(4):575-588. doi: 10.1111/j.1365-313x.2009.03981.x
Europe PMC | doi


Dimasi N, Flot D, Dupeux F, Márquez JA. (2007)

Expression, crystallization and X-ray data collection from microcrystals of the extracellular domain of the human inhibitory receptor expressed on myeloid cells IREM-1

Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 63(Pt 3):204-208. doi: 10.1107/s1744309107004903
Europe PMC | doi

Márquez JA, Galfré E, Dupeux F, Flot D, Moran O, Dimasi N. (2007)

The crystal structure of the extracellular domain of the inhibitor receptor expressed on myeloid cells IREM-1

J. Mol. Biol. 367(2):310-318. doi: 10.1016/j.jmb.2007.01.011
Europe PMC | doi

Ravelli RB, Haselmann-Weiss U, McGeehan JE, McCarthy AA, Marquez JA, Antony C, Frangakis AS, Stranzl G. (2007)

Plastic-embedded protein crystals

J Synchrotron Radiat 14(Pt 1):128-132. doi: 10.1107/s0909049506043111
Europe PMC | doi


Márquez J, Reinelt S, Koch B, Engelmann R, Hengstenberg W, Scheffzek K. (2006)

Structure of the full-length enzyme I of the phosphoenolpyruvate-dependent sugar phosphotransferase system

J. Biol. Chem. 281(43):32508-32515. doi: 10.1074/jbc.m513721200
Europe PMC | doi


Hothorn M, D'Angelo I, Márquez JA, Greiner S, Scheffzek K. (2004)

The invertase inhibitor Nt-CIF from tobacco: a highly thermostable four-helix bundle with an unusual N-terminal extension

J. Mol. Biol. 335(4):987-995. doi: 10.1016/j.jmb.2003.10.066
Europe PMC | doi


Márquez JA, Smith CI, Petoukhov MV, Lo Surdo P, Mattsson PT, Knekt M, Westlund A, Scheffzek K, Saraste M, Svergun DI. (2003)

Conformation of full-length Bruton tyrosine kinase (Btk) from synchrotron X-ray solution scattering

EMBO J. 22(18):4616-4624. doi: 10.1093/emboj/cdg448
Europe PMC | doi


Mijakovic I, Poncet S, Galinier A, Monedero V, Fieulaine S, Janin J, Nessler S, Marquez JA, Scheffzek K, Hasenbein S, Hengstenberg W, Deutscher J. (2002)

Pyrophosphate-producing protein dephosphorylation by HPr kinase/phosphorylase: a relic of early life?

Proc. Natl. Acad. Sci. U.S.A. 99(21):13442-13447. doi: 10.1073/pnas.212410399
Europe PMC | doi

Russell RB, Márquez JA, Hengstenberg W, Scheffzek K. (2002)

Evolutionary relationship between the bacterial HPr kinase and the ubiquitous PEP-carboxykinase: expanding the P-loop nucleotidyl transferase superfamily

FEBS Lett. 517(1-3):1-6. doi: 10.1016/s0014-5793(02)02518-8
Europe PMC | doi

Márquez JA, Hasenbein S, Koch B, Fieulaine S, Nessler S, Russell RB, Hengstenberg W, Scheffzek K. (2002)

Structure of the full-length HPr kinase/phosphatase from Staphylococcus xylosus at 1.95 A resolution: Mimicking the product/substrate of the phospho transfer reactions

Proc. Natl. Acad. Sci. U.S.A. 99(6):3458-3463. doi: 10.1073/pnas.052461499
Europe PMC | doi

Márquez JA, Saraste M. (2002)

Pleckstrin homology (PH) domains

In: Creighton T (ed.), Encyclopedia of Molecular Medicine. Encyclopedia of Molecular Medicine. John Wiley & Sons.doi: 10.1002/0471203076.emm0744
Europe PMC | doi


Ali R, Pascual-Ahuir A, Marquez JA, Malik KA, Serrano R. (2001)

Identification of Candida tropicalis HSR1, a gene of the heat-shock factor-related family, which confers salt tolerance in Saccharomyces cerevisiae.

Yeast 18(7):605-610. doi: 10.1002/yea.710
Europe PMC | doi


Castillo J, Rodrigo MI, Márquez JA, Zúñiga A, Franco L. (2000)

A pea nuclear protein that is induced by dehydration belongs to the vicilin superfamily.

Eur. J. Biochem. 267(8):2156-2165. doi: 10.1046/j.1432-1327.2000.01229.x
Europe PMC | doi


Márquez JA, Pascual-Ahuir A, Proft M, Serrano R. (1998)

The Ssn6-Tup1 repressor complex of Saccharomyces cerevisiae is involved in the osmotic induction of HOG-dependent and -independent genes

EMBO J. 17(9):2543-2553. doi: 10.1093/emboj/17.9.2543
Europe PMC | doi


Márquez JA, Serrano R. (1996)

Multiple transduction pathways regulate the sodium-extrusion gene PMR2/ENA1 during salt stress in yeast.

FEBS Lett. 382(1-2):89-92. doi: 10.1016/0014-5793(96)00157-3
Europe PMC | doi