EMBL Grenoble, 71 avenue des Martyrs, CS 90181, 38042 Grenoble Cedex 9, France


  • PhD 1997, National University of Ireland, Galway.
    Research associate, Utrecht University.
    Postdoctoral research at Massey University and Auckland University.
    Staff scientist at EMBL Grenoble.
    Team leader since 2007.


Total: 45 publication(s)


McCarthy AA, Barrett R, Beteva A, Caserotto H, Dobias F, Felisaz F, Giraud T, Guijarro M, Janocha R, Khadrouche A, Lentini M, Leonard GA, Lopez Marrero M, Malbet-Monaco S, McSweeney S, Papp G, Nurizzo D, Sinoir J, Rossi C, Surr J, Sorez C, Zander U, Svensson O, Theveneau P, Cipriani F, Mueller-Dieckmann C. (2018)

ID30B - a versatile beamline for macromolecular crystallography experiments at the ESRF.

J Synchrotron Radiat 25(Pt 4):1249-1260. doi: 10.1107/S1600577518007166
Europe PMC | doi

Aleksandrova N, Gutsche I, Kandiah E, Avilov SV, Petoukhov MV, Seiradake E, McCarthy AA. (2018)

Robo1 Forms a Compact Dimer-of-Dimers Assembly.

Structure S0969-2126(17):30402-30411. doi: 10.1016/j.str.2017.12.003
Europe PMC | doi

Skubak P, Arac D, Bowler MW, Correia A, Hoelz A, Larsen S, Leonard G, McCarthy A, McSweeney S, Mueller-Dieckmann C, Otten H, Salzman G, Pannu N. (2018)

A new MR-SAD algorithm for the automatic building of protein models from low-resolution X-ray data and a poor starting model

IUCrJ 5 doi: 10.1107/S2052252517017961
Europe PMC | doi


Papp G, Rossi C, Janocha R, Sorez C, Lopez-Marrero M, Astruc A, McCarthy A, Belrhali H, Bowler MW, Cipriani F. (2017)

Towards a compact and precise sample holder for macromolecular crystallography.

Acta Crystallogr D Struct Biol 73(Pt 10):829-840. doi: 10.1107/S2059798317013742
Europe PMC | doi


Simon B, Huart A, Temmerman K, Vahokoski J, Mertens H, Komadina D, Hoffmann J, Yumerefendi H, Svergun D, Kursula P, Schultz C, McCarthy A, Hart D, Wilmanns M. (2016)

Death-Associated Protein Kinase Activity Is Regulated by Coupled Calcium/Calmodulin Binding to Two Distinct Sites

Structure 24(6):851-861. doi: 10.1016/j.str.2016.03.020
Europe PMC | doi

Yang Z, Chen KM, Pandey RR, Homolka D, Reuter M, Janeiro BK, Sachidanandam R, Fauvarque MO, McCarthy AA, Pillai RS. (2016)

PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from Cytosolic Targets of the Mouse piRNA Pathway.

Mol. Cell 61(1):138-152. doi: 10.1016/j.molcel.2015.11.009
Europe PMC | doi


Caillat C, Macheboeuf P, Wu Y, McCarthy AA, Boeri-Erba E, Effantin G, Göttlinger HG, Weissenhorn W, Renesto P. (2015)

Asymmetric ring structure of Vps4 required for ESCRT-III disassembly.

Nat Commun 6 doi: 10.1038/ncomms9781
Europe PMC | doi

Enderle M, McCarthy A, Paithankar KS, Grininger M. (2015)

Crystallization and X-ray diffraction studies of a complete bacterial fatty-acid synthase type I.

Acta Crystallogr F Struct Biol Commun 71(Pt 11):1401-1407. doi: 10.1107/s2053230x15018336
Europe PMC | doi

Zander U, Bourenkov G, Popov AN, de Sanctis D, Svensson O, McCarthy AA, Round E, Gordeliy V, Mueller-Dieckmann C, Leonard GA. (2015)

MeshAndCollect: an automated multi-crystal data-collection workflow for synchrotron macromolecular crystallography beamlines.

Acta Crystallogr. D Biol. Crystallogr. 71(Pt 11):2328-2343. doi: 10.1107/s1399004715017927
Europe PMC | doi

Chen KM, Campbell E, Pandey RR, Yang Z, McCarthy AA, Pillai RS. (2015)

Metazoan Maelstrom is an RNA-binding protein that has evolved from an ancient nuclease active in protists.

RNA 21(5) doi: 10.1261/rna.049437.114
Europe PMC | doi

Mueller-Dieckmann C, Bowler MW, Carpentier P, Flot D, McCarthy AA, Nanao MH, Nurizzo D, Pernot P, Popov A, Round A, Royant A, de Sanctis D, von Stetten D, Leonard GA. (2015)

The status of the macromolecular crystallography beamlines at the European Synchrotron Radiation Facility

Eur Phys J Plus 130(4) doi: 10.1140/epjp/i2015-15070-0


Crepin T, Shalak VF, Yaremchuk AD, Vlasenko DO, McCarthy A, Negrutskii BS, Tukalo MA, El'skaya AV. (2014)

Mammalian translation elongation factor eEF1A2: X-ray structure and new features of GDP/GTP exchange mechanism in higher eukaryotes.

Nucleic Acids Res. 42(20):12939-12948. doi: 10.1093/nar/gku974
Europe PMC | doi

McGovern RE, McCarthy AA, Crowley PB. (2014)

Protein assembly mediated by sulfonatocalix[4]arene.

Chem. Commun. (Camb.) 50(72):10412-10415. doi: 10.1039/c4cc04897k
Europe PMC | doi

Cora E, Pandey RR, Xiol J, Taylor J, Sachidanandam R, McCarthy AA, Pillai RS. (2014)

The MID-PIWI module of Piwi proteins specifies nucleotide- and strand-biases of piRNAs

RNA 20(6):773-781. doi: 10.1261/rna.044701.114
Europe PMC | doi


Brockhauser S, Ravelli RB, McCarthy AA. (2013)

The use of a mini-κ goniometer head in macromolecular crystallography diffraction experiments

Acta Crystallogr. D Biol. Crystallogr. 69(Pt 7):1241-1251. doi: 10.1107/s0907444913003880
Europe PMC | doi

Monaco S, Gordon E, Bowler MW, Delagenière S, Guijarro M, Spruce D, Svensson O, McSweeney SM, McCarthy AA, Leonard G, Nanao MH. (2013)

Automatic processing of macromolecular crystallography X-ray diffraction data at the ESRF

J Appl Crystallogr 46(Pt 3):804-810. doi: 10.1107/s0021889813006195
Europe PMC | doi


Lallemand LA, Zubieta C, Lee SG, Wang Y, Acajjaoui S, Timmins J, McSweeney S, Jez JM, McCarthy JG, McCarthy AA. (2012)

A structural basis for the biosynthesis of the major chlorogenic acids found in coffee

Plant Physiol. 160(1):249-260. doi: 10.1104/pp.112.202051
Europe PMC | doi

Brockhauser S, Svensson O, Bowler MW, Nanao M, Gordon E, Leal RM, Popov A, Gerring M, McCarthy AA, Gotz A. (2012)

The use of workflows in the design and implementation of complex experiments in macromolecular crystallography

Acta Crystallogr. D Biol. Crystallogr. 68(Pt 8):975-984. doi: 10.1107/s090744491201863x
Europe PMC | doi

Lallemand LA, McCarthy JG, McSweeney S, McCarthy AA. (2012)

Purification, crystallization and preliminary X-ray diffraction analysis of a hydroxycinnamoyl-CoA shikimate/quinate hydroxycinnamoyltransferase (HCT) from Coffea canephora involved in chlorogenic acid biosynthesis

Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 68(Pt 7):824-828. doi: 10.1107/s1744309112019082
Europe PMC | doi


Kowalinski E, Lunardi T, McCarthy AA, Louber J, Brunel J, Grigorov B, Gerlier D, Cusack S. (2011)

Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA

Cell 147(2):423-435. doi: 10.1016/j.cell.2011.09.039
Europe PMC | doi

Brockhauser S, White KI, McCarthy AA, Ravelli RB. (2011)

Translation calibration of inverse-kappa goniometers in macromolecular crystallography

Acta Crystallogr., A, Found. Crystallogr. 67(Pt 3):219-228. doi: 10.1107/s0108767311004831
Europe PMC | doi


Badarau A, Firbank SJ, McCarthy AA, Banfield MJ, Dennison C. (2010)

Visualizing the metal-binding versatility of copper trafficking sites

Biochemistry 49(36):7798-7810. doi: 10.1021/bi101064w
Europe PMC | doi

Gabadinho J, Beteva A, Guijarro M, Rey-Bakaikoa V, Spruce D, Bowler MW, Brockhauser S, Flot D, Gordon EJ, Hall DR, Lavault B, McCarthy AA, McCarthy J, Mitchell E, Monaco S, Mueller-Dieckmann C, Nurizzo D, Ravelli RB, Thibault X, Walsh MA, Leonard GA, McSweeney SM. (2010)

MxCuBE: a synchrotron beamline control environment customized for macromolecular crystallography experiments

J Synchrotron Radiat 17(5):700-707. doi: 10.1107/s0909049510020005
Europe PMC | doi

Hinz A, Miguet N, Natrajan G, Usami Y, Yamanaka H, Renesto P, Hartlieb B, McCarthy AA, Simorre JP, Göttlinger H, Weissenhorn W. (2010)

Structural basis of HIV-1 tethering to membranes by the BST-2/tetherin ectodomain

Cell Host Microbe 7(4):314-323. doi: 10.1016/j.chom.2010.03.005
Europe PMC | doi


McCarthy AA, Brockhauser S, Nurizzo D, Theveneau P, Mairs T, Spruce D, Guijarro M, Lesourd M, Ravelli RB, McSweeney S. (2009)

A decade of user operation on the macromolecular crystallography MAD beamline ID14-4 at the ESRF

J Synchrotron Radiat 16(Pt 6):803-812. doi: 10.1107/s0909049509035377
Europe PMC | doi

Seiradake E, von Philipsborn AC, Henry M, Fritz M, Lortat-Jacob H, Jamin M, Hemrika W, Bastmeyer M, Cusack S, McCarthy AA. (2009)

Structure and functional relevance of the Slit2 homodimerization domain

EMBO Rep. 10(7):736-741. doi: 10.1038/embor.2009.95
Europe PMC | doi

Brooks MA, Ravelli RB, McCarthy AA, Strub K, Cusack S. (2009)

Structure of SRP14 from the Schizosaccharomyces pombe signal recognition particle

Acta Crystallogr. D Biol. Crystallogr. 65(Pt 5):421-433. doi: 10.1107/s0907444909005484
Europe PMC | doi

Dias A, Bouvier D, Crépin T, McCarthy AA, Hart DJ, Baudin F, Cusack S, Ruigrok RW. (2009)

The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

Nature 458(7240):914-918. doi: 10.1038/nature07745
Europe PMC | doi


Brockhauser S, Di Michiel M, McGeehan JE, McCarthy AA, Ravelli RBG. (2008)

X-ray tomographic reconstruction of macromolecular samples

J Appl Crystallogr 41:1057-1066. doi: 10.1107/S002188980802935X
Europe PMC | doi

Leal RMF, Teixeira SCM, Rey V, Forsyth VT, Mitchel EP, Brockhauser S, Di Michiel M, McGeehan JE, McCarthy A, Ravelli RBG. (2008)

Capturing the Shape of Macromolecular Crystals in 3D

ESRF Highlights 127-129.


Morlot C, Hemrika W, Romijn RA, Gros P, Cusack S, McCarthy AA. (2007)

Production of Slit2 LRR domains in mammalian cells for structural studies and the structure of human Slit2 domain 3

Acta Crystallogr. D Biol. Crystallogr. 63(Pt 9):961-968. doi: 10.1107/s0907444907035470
Europe PMC | doi

Morlot C, Thielens NM, Ravelli RB, Hemrika W, Romijn RA, Gros P, Cusack S, McCarthy AA. (2007)

Structural insights into the Slit-Robo complex

Proc. Natl. Acad. Sci. U.S.A. 104(38):14923-14928. doi: 10.1073/pnas.0705310104
Europe PMC | doi

Martinez Molina D, Wetterholm A, Kohl A, McCarthy AA, Niegowski D, Ohlson E, Hammarberg T, Eshaghi S, Haeggström JZ, Nordlund P. (2007)

Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase

Nature 448(7153):613-616. doi: 10.1038/nature06009
Europe PMC | doi

Morlot C, Hemrika W, Romijn RA, Gros P, Cusack S, McCarthy AA. (2007)

Cloning, expression, crystallization and preliminary X-ray analysis of the first two Ig domains from human roundabout 1 (Robo1)

Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 63(Pt 8):689-691. doi: 10.1107/S1744309107033027
Europe PMC | doi

McCarthy AA, McCarthy JG. (2007)

The structure of two N-methyltransferases from the caffeine biosynthetic pathway

Plant Physiol. 144(2):879-889. doi: 10.1104/pp.106.094854
Europe PMC | doi

McCarthy AA, Biget L, Lin C, Petiard V, Tanksley SD, McCarthy JG. (2007)

Cloning, expression, crystallization and preliminary X-ray analysis of the XMT and DXMT N-methyltransferases from Coffea canephora (robusta)

Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 63(Pt 4):304-307. doi: 10.1107/S1744309107009268
Europe PMC | doi

Papanikolau Y, Papadovasilaki M, Ravelli RB, McCarthy AA, Cusack S, Economou A, Petratos K. (2007)

Structure of dimeric SecA, the Escherichia coli preprotein translocase motor

J. Mol. Biol. 366(5):1545-1557. doi: 10.1016/j.jmb.2006.12.049
Europe PMC | doi

Ravelli RB, Haselmann-Weiss U, McGeehan JE, McCarthy AA, Marquez JA, Antony C, Frangakis AS, Stranzl G. (2007)

Plastic-embedded protein crystals

J Synchrotron Radiat 14(Pt 1):128-132. doi: 10.1107/s0909049506043111
Europe PMC | doi


Janssen BJ, Christodoulidou A, McCarthy A, Lambris JD, Gros P. (2006)

Structure of C3b reveals conformational changes that underlie complement activity

Nature 444(7116):213-216. doi: 10.1038/nature05172
Europe PMC | doi

Beteva A, Cipriani F, Cusack S, Delageniere S, Gabadinho J, Gordon EJ, Guijarro M, Hall DR, Larsen S, Launer L, Lavault CB, Leonard GA, Mairs T, McCarthy A, McCarthy J, Meyer J, Mitchell E, Monaco S, Nurizzo D, Pernot P, Pieritz R, Ravelli RG, Rey V, Shepard W, Spruce D, Stuart DI, Svensson O, Theveneau P, Thibault X, Turkenburg J, Walsh M, McSweeney SM. (2006)

High-throughput sample handling and data collection at synchrotrons: embedding the ESRF into the high-throughput gene-to-structure pipeline

Acta Crystallogr. D Biol. Crystallogr. 62(Pt 10):1162-1169. doi: 10.1107/s0907444906032859
Europe PMC | doi

Flot D, Gordon EJ, Hall DR, Leonard GA, McCarthy A, McCarthy J, McSweeney S, Mitchell E, Nurizzo D, Ravelli RG, Shepard W. (2006)

The care and nurture of undulator data sets

Acta Crystallogr. D Biol. Crystallogr. 62(Pt 1):65-71. doi: 10.1107/s0907444905032646
Europe PMC | doi


Arzt S, Beteva A, Cipriani F, Delageniere S, Felisaz F, Förstner G, Gordon E, Launer L, Lavault B, Leonard G, Mairs T, McCarthy A, McCarthy J, McSweeney S, Meyer J, Mitchell E, Monaco S, Nurizzo D, Ravelli R, Rey V, Shepard W, Spruce D, Svensson O, Theveneau P. (2005)

Automation of macromolecular crystallography beamlines

Prog. Biophys. Mol. Biol. 89(2):124-152. doi: 10.1016/j.pbiomolbio.2004.09.003
Europe PMC | doi


Mavrakis M, McCarthy AA, Roche S, Blondel D, Ruigrok RW. (2004)

Structure and function of the C-terminal domain of the polymerase cofactor of rabies virus

J. Mol. Biol. 343(4):819-831. doi: 10.1016/j.jmb.2004.08.071
Europe PMC | doi

Harel M, Aharoni A, Gaidukov L, Brumshtein B, Khersonsky O, Meged R, Dvir H, Ravelli RB, McCarthy A, Toker L, Silman I, Sussman JL, Tawfik DS. (2004)

Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes

Nat. Struct. Mol. Biol. 11(5):412-419. doi: 10.1038/nsmb767
Europe PMC | doi

McCarthy AA, Peterson NA, Knijff R, Baker EN. (2004)

Crystal structure of MshB from Mycobacterium tuberculosis, a deacetylase involved in mycothiol biosynthesis

J. Mol. Biol. 335(4):1131-1141. doi: 10.1016/j.jmb.2003.11.034
Europe PMC | doi