EMBL Grenoble, 71 avenue des Martyrs, CS 90181, 38042 Grenoble Cedex 9, France

Phone: +33 47620-7637

Biography

  • PhD 2005, MRC/Cambridge University, Cambridge, UK.
    Career Development Fellow, MRC Cambridge, UK.
    Beamline Scientist, ESRF, Grenoble 2007-2012.
    HDR 2012, Université Joseph Fourier, Grenoble, France.
    Staff scientist at EMBL Grenoble since 2012.

Publications

Total: 53 publication(s)

2017

Ampaw A, Carroll M, von Velsen J, Bhattasali D, Cohen A, Bowler MW, Jakeman DL. (2017)

Observing enzyme ternary transition state analogue complexes by 19F NMR spectroscopy

Chem Sci doi: 10.1039/C7SC04204C
doi

Papp G, Rossi C, Janocha R, Sorez C, Lopez-Marrero M, Astruc A, McCarthy A, Belrhali H, Bowler MW, Cipriani F. (2017)

Towards a compact and precise sample holder for macromolecular crystallography.

Acta Crystallogr D Struct Biol 73(Pt 10):829-840. doi: 10.1107/S2059798317013742
Europe PMC | doi

Jin Y, Molt RW, Pellegrini E, Cliff MJ, Bowler MW, Richards NGJ, Blackburn GM, Waltho JP. (2017)

Assessing the Influence of Mutation on GTPase Transition States using X-ray, 19F NMR, and DFT Approaches.

Angew Chem Int Ed Engl doi: 10.1002/anie.201703074
Europe PMC | doi

Bowler MG, Bowler DR, Bowler MW. (2017)

Raoult's law revisited: accurately predicting equilibrium relative humidity points for humidity control experiments.

J Appl Crystallogr 50(Pt 2):631-638. doi: 10.1107/S1600576717003636
Europe PMC | doi

Pellegrini E, Palencia A, Braun L, Kapp U, Bougdour A, Belrhali H, Bowler MW, Hakimi MA. (2017)

Structural Basis for the Subversion of MAP Kinase Signaling by an Intrinsically Disordered Parasite Secreted Agonist.

Structure 25:16-26. doi: 10.1016/j.str.2016.10.011
Europe PMC | doi

Jonnalagadda, S.V.R., Ornithopoulou, E., Orr, A., Mossou, E., Forsyth, T., Mitchell, E.P., Bowler, M.W., Mitraki, A. and Tamamis, P.. (2017)

Computational Design of Amyloid Self-Assembling Peptides Bearing Aromatic Residues and the Cell Adhesive Motif Arg-Gly-Asp

Mol. Syst. Des. Eng. doi: 10.1039/C7ME00016B
doi

Na Z, Yeo SP, Bharath SR, Bowler MW, Balıkçı E, Wang CI, Song H. (2017)

Structural basis for blocking PD-1-mediated immune suppression by therapeutic antibody pembrolizumab.

Cell Res. 27:147-150. doi: 10.1038/cr.2016.77
Europe PMC | doi

Papp G, Felisaz F, Sorez C, Lopez-Marrero M, Janocha R, Manjasetty B,Gobbo A, Belrhali H , Bowler MW, Cirpriani F. (2017)

FlexED8: the first member of a fast and flexible sample-changer family for macromolecular crystallography

Acta Crystallogr D Struct Biol D73:841-851. doi: 10.1107/S2059798317013596
Europe PMC | doi


2016

Tang X, Bharath SR, Piao S, Tan VQ, Bowler MW, Song H. (2016)

Structural basis for specific recognition of pre-snRNA by Gemin5.

Cell Res. 26(12):1353-1356. doi: 10.1038/cr.2016.133
Europe PMC | doi

Deidda G., Jonnalagadda SVR., Spies JW., Ranella A., Mossou E., Forsyth VT., Mitchell EP., Bowler MW., Tamamis P., Mitraki A.. (2016)

Self-assembled amyloid peptides with Arg-Gly-Asp (RGD) motifs as scaffolds for tissue engineering

ACS Biomater. Sci. Eng doi: 10.1021/acsbiomaterials.6b00570
doi

Nurizzo D, Bowler MW, Caserotto H, Dobias F, Giraud T, Surr J, Guichard N, Papp G, Guijarro M, Mueller-Dieckmann C, Flot D, McSweeney S, Cipriani F, Theveneau P, Leonard GA. (2016)

RoboDiff: combining a sample changer and goniometer for highly automated macromolecular crystallography experiments.

Acta Crystallogr D Struct Biol 72(Pt 8):966-975. doi: 10.1107/s205979831601158x
Europe PMC | doi

Tang X, Zhu Y, Baker SL, Bowler MW, Chen BJ, Chen C, Hogg JR, Goff SP, Song H. (2016)

Structural basis of suppression of host translation termination by Moloney Murine Leukemia Virus.

Nat Commun 7 doi: 10.1038/ncomms12070
Europe PMC | doi

Bowler MW, Svensson O, Nurizzo D. (2016)

Fully automatic macromolecular crystallography: the impact of MASSIF-1 on the optimum acquisition and quality of data

Crystallogr. Rev. 22:233-249. doi: 10.1080/0889311X.2016.1155050
doi


2015

Bowler MW, Nurizzo D, Barrett R, Beteva A, Bodin M, Caserotto H, Delagenière S, Dobias F, Flot D, Giraud T, Guichard N, Guijarro M, Lentini M, Leonard GA, McSweeney S, Oskarsson M, Schmidt W, Snigirev A, von Stetten D, Surr J, Svensson O, Theveneau P, Mueller-Dieckmann C. (2015)

MASSIF-1: a beamline dedicated to the fully automatic characterization and data collection from crystals of biological macromolecules.

J Synchrotron Radiat 22(Pt 6):1540-1547. doi: 10.1107/S1600577515016604
Europe PMC | doi

Svensson O, Malbet-Monaco S, Popov A, Nurizzo D, Bowler MW. (2015)

Fully automatic characterization and data collection from crystals of biological macromolecules.

Acta Crystallogr. D Biol. Crystallogr. 71(Pt 8):1757-1767. doi: 10.1107/s1399004715011918
Europe PMC | doi

Farci D, Bowler MW, Esposito F, McSweeney S, Tramontano E, Piano D. (2015)

Purification and characterization of DR_2577 (SlpA) a major S-layer protein from Deinococcus radiodurans.

Front Microbiol 6 doi: 10.3389/fmicb.2015.00414
Europe PMC | doi

Koromyslova AD, Leuthold MM, Bowler MW, Hansman GS. (2015)

The sweet quartet: Binding of fucose to the norovirus capsid.

Virology 483:203-208. doi: 10.1016/j.virol.2015.04.006
Europe PMC | doi

Bowler MW, Mueller U, Weiss MS, Sanchez-Weatherby J, Sorensen TLM, Thunnissen MMGM, Ursby T, Gobbo A, Russi S, Bowler MG, Brockhauser S, Svensson O, Cipriani F. (2015)

Automation and Experience of Controlled Crystal Dehydration: Results from the European Synchrotron HC1 Collaboration

Cryst Growth Des 15(3):1043-1054. doi: 10.1021/cg500890r
doi

De Maria Antolinos A, Pernot P, Brennich ME, Kieffer J, Bowler MW, Delageniere S, Ohlsson S, Malbet Monaco S, Ashton A, Franke D, Svergun D, McSweeney S, Gordon E, Round A. (2015)

ISPyB for BioSAXS, the gateway to user autonomy in solution scattering experiments.

Acta Crystallogr. D Biol. Crystallogr. 71(Pt 1):76-85. doi: 10.1107/s1399004714019609
Europe PMC | doi

Mueller-Dieckmann C, Bowler MW, Carpentier P, Flot D, McCarthy AA, Nanao MH, Nurizzo D, Pernot P, Popov A, Round A, Royant A, de Sanctis D, von Stetten D, Leonard GA. (2015)

The status of the macromolecular crystallography beamlines at the European Synchrotron Radiation Facility

Eur Phys J Plus 130 doi: 10.1140/epjp/i2015-15070-0
doi


2014

Jin Y, Bhattasali D, Pellegrini E, Forget SM, Baxter NJ, Cliff MJ, Bowler MW, Jakeman DL, Blackburn GM, Waltho JP. (2014)

α-Fluorophosphonates reveal how a phosphomutase conserves transition state conformation over hexose recognition in its two-step reaction.

Proc. Natl. Acad. Sci. U.S.A. 111(34):12384-12389. doi: 10.1073/pnas.1402850111
Europe PMC | doi

Farci D, Bowler MW, Kirkpatrick J, McSweeney S, Tramontano E, Piano D. (2014)

New features of the cell wall of the radio-resistant bacterium Deinococcus radiodurans

Biochim. Biophys. Acta 1838(7):1978-1984. doi: 10.1016/j.bbamem.2014.02.014
Europe PMC | doi

Wu D, Muhlrad D, Bowler MW, Jiang S, Liu Z, Parker R, Song H. (2014)

Lsm2 and Lsm3 bridge the interaction of the Lsm1-7 complex with Pat1 for decapping activation

Cell Res. 24(2):233-246. doi: 10.1038/cr.2013.152
Europe PMC | doi

Bowler MG, Bowler MW. (2014)

Measurement of the intrinsic variability within protein crystals: implications for sample-evaluation and data-collection strategies

Acta Crystallogr F Struct Biol Commun 70(Pt 1):127-132. doi: 10.1107/s2053230x13032007
Europe PMC | doi


2013

Fan H, Dong Y, Wu D, Bowler MW, Zhang L, Song H. (2013)

QsIA disrupts LasR dimerization in antiactivation of bacterial quorum sensing

Proc. Natl. Acad. Sci. U.S.A. 110(51):20765-20770. doi: 10.1073/pnas.1314415110
Europe PMC | doi

Ferrer JL, Larive NA, Bowler MW, Nurizzo D. (2013)

Recent progress in robot-based systems for crystallography and their contribution to drug discovery

Expert Opin Drug Discov 8(7):835-847. doi: 10.1517/17460441.2013.793666
Europe PMC | doi

Bowler MW. (2013)

Conformational dynamics in phosphoglycerate kinase, an open and shut case?

FEBS Lett. 587(13):1878-1883. doi: 10.1016/j.febslet.2013.05.012
Europe PMC | doi

Monaco S, Gordon E, Bowler MW, Delagenière S, Guijarro M, Spruce D, Svensson O, McSweeney SM, McCarthy AA, Leonard G, Nanao MH. (2013)

Automatic processing of macromolecular crystallography X-ray diffraction data at the ESRF

J Appl Crystallogr 46(Pt 3):804-810. doi: 10.1107/s0021889813006195
Europe PMC | doi

Bowler MW, Nurizzo D. (2013)

Le rayonnement synchrotron : comprendre la relation structure-fonction des macromolecules biologiques

Reflets phys. 2013(34-35):48-53. doi: 10.1051/refdp/201334048
Europe PMC | doi


2012

Jin Y, Cliff MJ, Baxter NJ, Dannatt HR, Hounslow AM, Bowler MW, Blackburn GM, Waltho JP. (2012)

Charge-balanced metal fluoride complexes for protein kinase A with adenosine diphosphate and substrate peptide SP20

Angew. Chem. Int. Ed. Engl. 51(49):12242-12245. doi: 10.1002/anie.201204266
Europe PMC | doi

Lai T, Cho H, Liu Z, Bowler MW, Piao S, Parker R, Kim YK, Song H. (2012)

Structural basis of the PNRC2-mediated link between mrna surveillance and decapping

Structure 20(12):2025-2037. doi: 10.1016/j.str.2012.09.009
Europe PMC | doi

Lim SC, Bowler MW, Lai TF, Song H. (2012)

The Ighmbp2 helicase structure reveals the molecular basis for disease-causing mutations in DMSA1

Nucleic Acids Res. 40(21):11009-11022. doi: 10.1093/nar/gks792
Europe PMC | doi

Blackburn GM, Bowler MW, Jin Y, Waltho JP. (2012)

Reflections on biocatalysis involving phosphorus

Biochemistry Mosc. 77(10):1083-1096. doi: 10.1134/s000629791210001x
Europe PMC | doi

Brockhauser S, Svensson O, Bowler MW, Nanao M, Gordon E, Leal RM, Popov A, Gerring M, McCarthy AA, Gotz A. (2012)

The use of workflows in the design and implementation of complex experiments in macromolecular crystallography

Acta Crystallogr. D Biol. Crystallogr. 68(Pt 8):975-984. doi: 10.1107/s090744491201863x
Europe PMC | doi

Griffin JL, Bowler MW, Baxter NJ, Leigh KN, Dannatt HR, Hounslow AM, Blackburn GM, Webster CE, Cliff MJ, Waltho JP. (2012)

Near attack conformers dominate β-phosphoglucomutase complexes where geometry and charge distribution reflect those of substrate

Proc. Natl. Acad. Sci. U.S.A. 109(18):6910-6915. doi: 10.1073/pnas.1116855109
Europe PMC | doi

Wheeler MJ, Russi S, Bowler MG, Bowler MW. (2012)

Measurement of the equilibrium relative humidity for common precipitant concentrations: facilitating controlled dehydration experiments

Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 68(Pt 1):111-114. doi: 10.1107/s1744309111054029
Europe PMC | doi

Wu D, Jiang S, Bowler MW, Song H. (2012)

Crystal structures of Lsm3, Lsm4 and Lsm5/6/7 from Schizosaccharomyces pombe

PLoS ONE 7(5):e36768. doi: 10.1371/journal.pone.0036768
Europe PMC | doi


2011

Pellegrini E, Piano D, Bowler MW. (2011)

Direct cryocooling of naked crystals: are cryoprotection agents always necessary?

Acta Crystallogr. D Biol. Crystallogr. 67(Pt 10):902-906. doi: 10.1107/s0907444911031210
Europe PMC | doi

Russi S, Juers DH, Sanchez-Weatherby J, Pellegrini E, Mossou E, Forsyth VT, Huet J, Gobbo A, Felisaz F, Moya R, McSweeney SM, Cusack S, Cipriani F, Bowler MW. (2011)

Inducing phase changes in crystals of macromolecules: status and perspectives for controlled crystal dehydration

J. Struct. Biol. 175(2):236-243. doi: 10.1016/j.jsb.2011.03.002
Europe PMC | doi

Lallemand P, Chaloin L, Roy B, Barman T, Bowler MW, Lionne C. (2011)

Interaction of human 3-phosphoglycerate kinase with its two substrates: is substrate antagonism a kinetic advantage?

J. Mol. Biol. 409(5):742-757. doi: 10.1016/j.jmb.2011.04.048
Europe PMC | doi

Zerrad L, Merli A, Schröder GF, Varga A, Gráczer É, Pernot P, Round A, Vas M, Bowler MW. (2011)

A spring-loaded release mechanism regulates domain movement and catalysis in phosphoglycerate kinase

J. Biol. Chem. 286(16):14040-14048. doi: 10.1074/jbc.m110.206813
Europe PMC | doi


2010

Gabadinho J, Beteva A, Guijarro M, Rey-Bakaikoa V, Spruce D, Bowler MW, Brockhauser S, Flot D, Gordon EJ, Hall DR, Lavault B, McCarthy AA, McCarthy J, Mitchell E, Monaco S, Mueller-Dieckmann C, Nurizzo D, Ravelli RB, Thibault X, Walsh MA, Leonard GA, McSweeney SM. (2010)

MxCuBE: a synchrotron beamline control environment customized for macromolecular crystallography experiments

J Synchrotron Radiat 17(5):700-707. doi: 10.1107/s0909049510020005
Europe PMC | doi

Bowler MW, Guijarro M, Petitdemange S, Baker I, Svensson O, Burghammer M, Mueller-Dieckmann C, Gordon EJ, Flot D, McSweeney SM, Leonard GA. (2010)

Diffraction cartography: applying microbeams to macromolecular crystallography sample evaluation and data collection

Acta Crystallogr. D Biol. Crystallogr. 66(Pt 8):855-864. doi: 10.1107/s0907444910019591
Europe PMC | doi

Cliff MJ, Bowler MW, Varga A, Marston JP, Szabó J, Hounslow AM, Baxter NJ, Blackburn GM, Vas M, Waltho JP. (2010)

Transition state analogue structures of human phosphoglycerate kinase establish the importance of charge balance in catalysis

J. Am. Chem. Soc. 132(18):6507-6516. doi: 10.1021/ja100974t
Europe PMC | doi

Baxter NJ, Bowler MW, Alizadeh T, Cliff MJ, Hounslow AM, Wu B, Berkowitz DB, Williams NH, Blackburn GM, Waltho JP. (2010)

Atomic details of near-transition state conformers for enzyme phosphoryl transfer revealed by MgF-3 rather than by phosphoranes

Proc. Natl. Acad. Sci. U.S.A. 107(10):4555-4560. doi: 10.1073/pnas.0910333106
Europe PMC | doi

Bowler MW, Cliff MJ, Waltho JP, Blackburn GM. (2010)

Why did Nature select phosphate for its dominant roles in biology?

New J Chem 34:784-794.
Europe PMC

Bowler MW, Cliff MJ, Waltho JP, Blackburn GM. (2010)

大自然为什么选择磷主导生命 [Why did nature select phosphate for its dominant roles in biology?]

Sci China Ser B-Chem 40(7):927-939.


2009

Sanchez-Weatherby J, Bowler MW, Huet J, Gobbo A, Felisaz F, Lavault B, Moya R, Kadlec J, Ravelli RB, Cipriani F. (2009)

Improving diffraction by humidity control: a novel device compatible with X-ray beamlines

Acta Crystallogr. D Biol. Crystallogr. 65(Pt 12):1237-1246. doi: 10.1107/s0907444909037822
Europe PMC | doi

Baxter NJ, Hounslow AM, Bowler MW, Williams NH, Blackburn GM, Waltho JP. (2009)

MgF(3)(-) and alpha-galactose 1-phosphate in the active site of beta-phosphoglucomutase form a transition state analogue of phosphoryl transfer

J. Am. Chem. Soc. 131(45):16334-16335. doi: 10.1021/ja905972m
Europe PMC | doi


2007

Bowler MW, Montgomery MG, Leslie AG, Walker JE. (2007)

Ground state structure of F1-ATPase from bovine heart mitochondria at 1.9 A resolution

J. Biol. Chem. 282(19):14238-14242. doi: 10.1074/jbc.m700203200
Europe PMC | doi


2006

Bowler MW, Montgomery MG, Leslie AG, Walker JE. (2006)

Reproducible improvements in order and diffraction limit of crystals of bovine mitochondrial F(1)-ATPase by controlled dehydration

Acta Crystallogr. D Biol. Crystallogr. 62(Pt 9):991-995. doi: 10.1107/s0907444906020877
Europe PMC | doi

Bowler MW, Montgomery MG, Leslie AG, Walker JE. (2006)

How azide inhibits ATP hydrolysis by the F-ATPases

Proc. Natl. Acad. Sci. U.S.A. 103(23):8646-8649. doi: 10.1073/pnas.0602915103
Europe PMC | doi


2003

Kuo A, Bowler MW, Zimmer J, Antcliff JF, Doyle DA. (2003)

Increasing the diffraction limit and internal order of a membrane protein crystal by dehydration

J. Struct. Biol. 141(2):97-102. doi: 10.1016/s1047-8477(02)00633-0
Europe PMC | doi